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Hypotheses

1,878 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
h-ae1b2bebTranscriptional Autophagy-Lysosome Coupling0.760.71FOXO1promoted2026-04-02sda-2026-04-01-gap-011
h-862600b1sTREM2 as Biomarker of Cystatin-C Therapeutic Efficacy0.760.58TREM2proposed2026-04-17SDA-2026-04-16-gap-pubmed-20260410-150544-e3a2eab9
h-dffb42d9deIntegrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2, and Neurogranin0.760.68CHI3L1/TREM2/NRGNproposed2026-04-22SDA-2026-04-06-gap-debate-20260406-062039-3b945972
h-trem2-f48baa0cTREM2-APOE4 Co-targeting — Simultaneous Correction of Lipid Sensing and Clearanc0.760.67TREM2, APOEproposed2026-04-05SDA-2026-04-02-gap-001
h-1e564178Multi-Modal Stress Response Harmonization0.760.60NR3C1/CRH/TNFApromoted2026-04-02sda-2026-04-01-gap-012
h-70bc216f06p16^INK4a-CCF Axis as Senolytic Timing Biomarker0.760.75CDKN2A, CGAS, STING1proposed2026-04-21SDA-2026-04-07-gap-debate-20260406-062101-724971bc
h-cb833ed8Senescence-Activated NAD+ Depletion Rescue0.760.60CD38/NAMPTpromoted2026-04-02sda-2026-04-01-gap-013
hyp_test_f358dd4bTest: TREM2 enhances amyloid clearance0.760.33TREM2proposed2026-04-17test-hypothesis-fixtures-v1
h-seaad-56fa6428GFAP-Positive Reactive Astrocyte Subtype Delineation0.750.70GFAPpromoted2026-04-03analysis-SEAAD-20260402
h-e27f712688TREM2-Dependent Switch Hypothesis: TREM2 Agonism Redirects SPP1 Signaling from D0.750.72TREM2proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-062118-2cdbb0dd
h-655c7f33Temporal SPP1 Inhibition During Critical Windows0.750.80SPP1promoted2026-04-16SDA-2026-04-15-gap-pubmed-20260406-062118-e3613755
h-593b3464ω-3 Docosahexaenoic Acid (DHA) Epoxide Generation via CYP2J2 to Protect Synaptic0.750.75CYP2J2/ω-3 DHA epoxides (sEH inhibition)proposed2026-04-26SDA-2026-04-16-frontier-lipidomics-dcdbc360
h-var-bc4357c8c5Dopaminergic Ventral Tegmental-Hippocampal Circuit Protection0.750.65MAPTproposed2026-04-07SDA-2026-04-03-26abc5e5f9f2
hyp-lyso-snca-3a610eGBA1 Loss Triggers a TFEB-to-TFE3 Compensatory Switch in A9 Dopaminergic Neurons0.750.65TFEBactive2026-04-28
h-c704dd991041Tau/MAP6 ratio as a master switch for microtubule dynamics plasticity0.750.75MAPTproposed2026-04-26paper-39257379
h-e3557d75fa56Tau dysfunction destabilizes labile pool0.750.75MAPTproposed2026-04-26paper-40040809
h-dd0ccf93cbIron-driven lipid peroxidation and GPX4 failure create a ferroptotic amplificati0.750.78GPX4; SLC7A11; ACSL4; TFRC; FTH1; FTLproposed2026-04-26SDA-2026-04-26-gap-pubmed-20260410-181140-0af1a353-debate
h-16591043d1Selective blockade of classical-pathway activation downstream of C1q will reduce0.750.74C1QA,C1QB,C1QC,C1R,C1S,C4A,C4B,C3proposed2026-04-25SDA-2026-04-25-gapdebate-afba1a80bd
h-2dd1b7359dVHH-Fc Fusion Constructs with Separate BBB-Targeting Moiety0.750.72FCGRT (FcRn); FCGRT-β2M complexproposed2026-04-22SDA-2026-04-02-gap-bbb-antibody-transport
h-de0d4364Selective Acid Sphingomyelinase Modulation Therapy0.750.80SMPD1promoted2026-04-02SDA-2026-04-01-gap-lipid-rafts-2026-04-01
h-immunity-6e54942bAstrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate0.750.75C3, C3aR, NFKB1, PPARGC1Aopen2026-04-24
h-67914e81PDE4 Inhibition as Inflammatory Reset for PD Oligodendrocytes0.750.68PDE4A, PDE4B, PDE4Dpromoted2026-04-14SDA-2026-04-13-gap-pubmed-20260410-150500-e110aab9
h-var-799795f6afTREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming0.750.78TREM2, CSF1Rproposed2026-04-12SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-73e9899eC1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV Interneuron Input Eli0.750.68C1QA, C1QBproposed2026-04-16SDA-2026-04-15-gap-debate-20260410-112441-f2afffb3
hyp-lyso-snca-c9e088GBA1-Deficiency Disrupts Mitochondrial- Lysosomal Contact Sites by Reducing Miro0.750.68GBA1active2026-04-28
h-var-159030513dMetabolic NAD+ Salvage Pathway Enhancement Through NAMPT Overexpression0.750.78NAMPTpromoted2026-04-12SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-SDA-2026-04-26-gapCirculating Soluble PDGFRβ Reflects Pericyte Loss and Precedes Cognitive Decline0.740.27PDGFRβproposed2026-04-26SDA-2026-04-26-gap-20260426-002803
h-3156f6bcd349GPX4 reserve failure gates selective ALS motor-neuron ferroptosis0.740.72GPX4proposed2026-04-26SDA-2026-04-26-gap-ferroptosis-mnd-768eaeba1be3
h-0e0cc0c1Circadian-Synchronized Proteostasis Enhancement0.740.60CLOCK/ULK1promoted2026-04-02sda-2026-04-01-gap-012
h-var-ddd5c9bcc8TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging0.740.78TREM2proposed2026-04-12SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-seaad-fa5ea82dAPOE Isoform Expression Across Glial Subtypes0.740.55APOEproposed2026-04-03analysis-SEAAD-20260402
hyp-lyso-snca-3f4d11PD-Associated GWAS Variants in CTSO and CTSF Genes Create a Synthetic Lethal Int0.740.58GBA1active2026-04-28
h-cd60e2ecThalamocortical Synchrony Restoration via NMDA Modulation0.740.60GRIN2Bproposed2026-04-04SDA-2026-04-03-26abc5e5f9f2
h-a23cc3c8b9H3: G3BP1 as Nucleation Hub for TDP-43/FUS Seeding0.740.78G3BP1, TARDBP, FUSproposed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-041428-4c4414ad
h-73124693BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imbalance via PV Intern0.740.72NRG1/ERBB4promoted2026-04-16SDA-2026-04-15-gap-pubmed-20260411-093843-0a9326c2
h-072b2f5dSmartphone-Detected Motor Variability Correction0.740.50DRD2/SNCApromoted2026-04-02sda-2026-04-01-gap-012
h-1a34778fSenescent Cell Mitochondrial DNA Release0.740.50CGAS/STING1/DNASE2debated2026-04-02sda-2026-04-01-gap-013
h-fd1562a3Near-infrared light therapy stimulates COX4-dependent mitochondrial motility enh0.740.50COX4I1debated2026-04-02sda-2026-04-01-gap-v2-89432b95
h-c9c79e3eAPOE4-Selective Lipid Nanoemulsion Therapy0.740.60APOEproposed2026-04-03sda-2026-04-01-gap-auto-fd6b1635d9
h-180807e5APOE-TREM2 Interaction Modulation0.740.80TREM2promoted2026-04-03sda-2026-04-01-gap-auto-fd6b1635d9
h-f4a63646Complement-SASP Amplification Cascade as Mechanistic Link0.740.65C1QA, C1QB, C3, IL1B, NFKB1promoted2026-04-17SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974
h-d2722680Epigenetic Memory Erasure via TET2 Activation0.740.70TET2debated2026-04-02sda-2026-04-01-gap-007
h-adfcd3f146TREM2 Crosstalk and Synergistic Activation of Phagocytic Transcriptome0.740.72TREM2/DAP12 (TYROBP)proposed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-062118-e3613755
h-6726853448NRF2 failure lowers antioxidant reserve and permits recurrent mitochondrial ROS 0.740.77NFE2L2; KEAP1; HMOX1; NQO1; GCLC; TXNRD1proposed2026-04-26SDA-2026-04-26-gap-pubmed-20260410-181140-0af1a353-debate
h-cb692686e2Tau missorting transitions into an autonomous tau-seeding state after transient 0.740.78MAPTproposed2026-04-25SDA-2026-04-25-gapdebate-98a600b3ed
h-fc43140722Mutant-dependent amplification is context-dependent and strongest in microglia a0.740.75LRRK2,RAB10proposed2026-04-25SDA-2026-04-25-gapdebate-9180363b7c
h-9bcba57f3fVPS35 retromer activation prevents endosomal tau templating across all brain reg0.740.67VPS35proposed2026-04-21SDA-2026-04-07-gap-debate-20260406-062052-946439a8
h-0b9e4152MEF2C-Dependent Synaptic Gene Regulation0.740.55MEF2Cpromoted2026-04-15SDA-2026-04-15-gap-pubmed-20260411-075338-35f913fb
h-var-59fc393ba6Microglial-Mediated Tau Clearance Dysfunction via TREM2 Receptor Impairment0.740.78MAPTproposed2026-04-12SDA-2026-04-03-26abc5e5f9f2
h-9b862d73adC9orf72 Hexanucleotide Repeat Dipeptide Repeat Proteins Inhibit Nucleocytoplasmi0.740.80NUP98proposed2026-04-26legacy-pre-pipeline-import-v1
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