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Hypotheses

1,886 items
IdTitleComposite ScoreConfidence ScoreTarget GeneStatusCreated AtAnalysis Id
h-3d993b5dMetabolic Circuit Breaker via Lipid Droplet Modulation0.710.60PLIN2debated2026-04-02sda-2026-04-01-gap-009
h-5e68b4adAutophagosome Maturation Checkpoint Control0.710.73STX17debated2026-04-02sda-2026-04-01-gap-011
h-82922df8Matrix Stiffness Normalization via Targeted Lysyl Oxidase Inhibition0.710.65LOX/LOXL1-4debated2026-04-02sda-2026-04-01-gap-v2-ee5a5023
h-immunity-c64967abTREM2-APOE4 Axis Drives Metabolic Inflexibility in DAM0.710.72TREM2, APOE4, LDHAopen2026-04-24
h-var-bed9f3b7edTREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegeneration0.710.80TREM2superseded2026-04-12SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-9d29bfe5Membrane Cholesterol Gradient Modulators0.710.85ABCA1/LDLR/SREBF2promoted2026-04-02SDA-2026-04-01-gap-lipid-rafts-2026-04-01
h-8597755bOrexin-Microglia Modulation Therapy0.710.50HCRTR2debated2026-04-02sda-2026-04-01-gap-v2-18cf98ca
h-1b47a73770APOE4-driven lysosome-to-ER cholesterol transport failure reduces ER-accessible 0.710.79NPC1proposed2026-04-25SDA-2026-04-25-gapdebate-f4c8357045
h-587ea473Creatine Kinase System Capacity as Neural Energy Reserve Biomarker0.710.50CKBproposed2026-04-17SDA-2026-04-04-gap-debate-20260403-222618-c698b06a
h-d7121bccTET2-Mediated Demethylation Rejuvenation Therapy0.710.68TET2debated2026-04-02sda-2026-04-01-gap-v2-bc5f270e
h-b3d6ecc2Lysosomal Enzyme Trafficking Correction0.710.65IGF2Rdebated2026-04-02sda-2026-04-01-gap-011
h-var-18aae53fe9TREM2-ASM Crosstalk in Microglial Lysosomal Senescence0.710.78SMPD1promoted2026-04-12SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-fb56c8a0Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulation0.710.70SDC1debated2026-04-02sda-2026-04-01-gap-v2-ee5a5023
h-SDA-2026-04-26-gapCSF/Plasma AQP4 Polarization Index as a Novel Biomarker of Astrocyte Glymphatic 0.710.50AQP4proposed2026-04-26SDA-2026-04-26-gap-20260426-001521
h-SDA-2026-04-26-gapPlasma Claudin-5 Proteolytic Fragments Distinguish Paracellular BBB Breakdown fr0.710.41CLDN5proposed2026-04-26SDA-2026-04-26-gap-20260426-002803
h-SDA-2026-04-26-gapSoluble PDGFRβ as a Peripheral Indicator of Pericyte-Mediated Blood-Brain Barrie0.710.43PDGFRB (Platelet-Derived Growth Factor Receptor Beta)proposed2026-04-26SDA-2026-04-26-gap-debate-20260426-011448-7c85f5dc
h-5cbf67bf98Spatiotemporal coupling between TRPML1-mediated lysosomal calcium release and ca0.700.65TRPML1/MCOLN1proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-062150-387cb0ba
hyp_test_0a572efbTest: TREM2 enhances amyloid clearance0.700.40TREM2archived2026-04-04test-hypothesis-fixtures-v1
h-2c776894Ferroptosis Inhibition for α-Synuclein Neuroprotection0.700.75GPX4promoted2026-04-04SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402
h-470ff83eMicroglial Efferocytosis Enhancement via GPR32 Superagonists0.700.50CMKLR1debated2026-04-02sda-2026-04-01-gap-014
h-17a2da3fAstrocyte-Neuron Metabolic Coupling Titration0.700.50BDH1proposed2026-04-17SDA-2026-04-03-gap-debate-20260403-222618-2709aad9
h-183fff58TDP-43 Pathology Disrupts the HGS-PYGB Autophagy Receptor Cascade in Motor Neuro0.700.72TARDBP (TDP-43), HGS, PYGBproposed2026-04-26SDA-2026-04-07-gap-pubmed-20260406-062212-ca78691c
h-21d25124TLR4/MyD88/NF-κB Axis Blockade to Interrupt LPS-Mediated Gut-Brain Neuroinflamma0.700.68TLR4, MyD88 (MYD88), NF-κB (NFKB1)promoted2026-04-17SDA-2026-04-16-gap-20260416-121711
h-f99ce4caPurinergic P2Y12 Inverse Agonist Therapy0.700.65P2RY12debated2026-04-02sda-2026-04-01-gap-v2-691b42f1
h-ab41908bAryl Hydrocarbon Receptor (AHR) Activation in B Cells Determines AQP4 Tolerance 0.700.55AHR, IL10, TNFRSF13B, TIGIT, FOXP3promoted2026-04-14SDA-2026-04-13-gap-pubmed-20260410-142329-c1db787b
h-0e614ae4Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration0.700.70SIRT3debated2026-04-02SDA-2026-04-04-gap-epigenetic-reprog-b685190e
h-03e31e80DAMP-Scavenging Microglial Reset0.700.66HMGB1, S100 proteinsproposed2026-04-04SDA-2026-04-04-gap-neuroinflammation-microglial-20260404
h-5daecb6eMicroglial Purinergic Reprogramming0.700.58P2RY12debated2026-04-02sda-2026-04-01-gap-005
h-3d545f4eTargeted Butyrate Supplementation for Microglial Phenotype Modulation0.700.70GPR109Apromoted2026-04-03SDA-2026-04-01-gap-20260401-225149
h-92cfd75109NRF2-Mediated Proteostatic Convergence: Shared Oxidative Stress Response Failure0.700.75NFE2L2,KEAP1,HMOX1,SQSTM1,PSMB5proposed2026-04-28
h-2fe683915dLysosomal Acidification Failure: Convergent GBA1/LAMP2A–mediated Autophagy Dysfu0.700.77GBA1,LAMP2A,SCARB2,CTSB,CTSD,TFEBproposed2026-04-28
hyp-lyso-snca-cf55ffVPS35 Retromer Dysfunction Creates a GCase Trafficking Bottleneck that Synergize0.700.75VPS35active2026-04-28
hyp-lyso-snca-357729Glucosylceramide Accumulation from GCase Deficiency Disrupts SNX5-Mediated Retro0.700.78GBA1active2026-04-28
9a0b729f-5882-442b-8Test hypothesis 00.700.43proposed2026-04-27
ab0857a9-de30-44f8-9Test hypothesis 00.700.43proposed2026-04-27
aa3eca6b-10a6-4d1e-8Test hypothesis 00.700.43proposed2026-04-27
c19ee425-4805-41a9-9Test hypothesis 00.700.43proposed2026-04-27
h-d8e13922ed22MAP6-CRMPS cooperative phosphorylation by GSK3β0.700.70MAP6/CRMP2proposed2026-04-26paper-34025352
h-f05d11119fPericyte-targeted senolysis or senomorphic therapy will benefit only an early bi0.700.64PDGFRB, CDKN2A, CDKN1A, BCL2, BCL2L1proposed2026-04-25SDA-2026-04-25-gapdebate-de5dfc4391
h-6aebb76ee3SCFA-Producing Bacterial Depletion → Loss of Neuroprotective Microenvironment0.700.74HDAC3, GPR41 (FFAR3), GPR43 (FFAR2), Nrf2, HMOX1proposed2026-04-22sda-2026-04-01-gap-20260401-225155
h-aa1f5de5cdTREM2 haploinsufficiency dysregulates microglial synaptic surveillance, switchin0.700.22TREM2, TYROBP (DAP12), APOEproposed2026-04-22SDA-2026-04-02-gap-synaptic-pruning-microglia
h-2c8ecd5282AAV-Mediated APOE2/APOE3 Gene Delivery to Convert APOE Genotype0.700.78APOEproposed2026-04-22SDA-2026-04-02-gap-apoe4-targeting
h-50d1ee2566Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to Form Toxic, Irreversible Stres0.700.68ATXN2proposed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-041428-e14e6524
h-2850184c77NAD+ Decline and SIRT1 Deficiency Drive Epigenetic Reprogramming Toward Senescen0.700.70SIRT1/NAMPT/PPARGC1Aproposed2026-04-22SDA-2026-04-06-gap-pubmed-20260406-041439-5f43216e
h-4e0d44f33eTRIM21 as a 'Phase Separation Thermostat' via Catalytic Reversibility0.700.72TRIM21proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041423-2d1db50c
h-22d6b643b8Metabolic Coupling Disruption Sensitizes Motor Neuron mPTP Threshold0.700.72PDH (pyruvate dehydrogenase), MCT1/2, PDK, mPTP (ANT/VDAC/Cyproposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-062141-611cf046
h-49722750cfm6A RNA Modification as Address Code for Granule Targeting0.700.72METTL3, METTL14, FTO, ALKBH5, YTHDF1, YTHDF2, YTHDC1proposed2026-04-21SDA-2026-04-07-gap-pubmed-20260406-041428-53b81741
h-53fd55dc89FOXO3-Pioneer Factor Complex Stabilizes Heterochromatin Under Oxidative Stress0.700.70FOXO3; SIRT1proposed2026-04-21SDA-2026-04-10-gap-20260410-091440
h-58e4635aSASP-Mediated Complement Cascade Amplification0.700.70C1Q/C3promoted2026-04-02sda-2026-04-01-gap-013
h-db6aa4b1Mechanosensitive Ion Channel Reprogramming0.700.55PIEZO1 and KCNK2debated2026-04-02sda-2026-04-01-gap-007
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