| h-9a862b0e02 | TFEB-Dependent Lysosome Biogenesis | 0.69 | 0.68 | TFEB/TFE3 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062150-a6cc7467 |
| h-f3751a9ee4 | Time-Limited AQP4 Inhibition for Acute Cytotoxic Edema Followed by Therapeutic R | 0.69 | 0.68 | AQP4 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-7e1dc0b2 |
| h-ebefda890e | Loss of AQP4 Polarization Impairs Glymphatic Perivascular Influx, Causing Metabo | 0.69 | 0.78 | AQP4 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-ce0abc1e |
| h-2a9928e512 | Rab27A/B-mediated exosomal tau secretion from microglia drives frontal cortex pr | 0.69 | 0.66 | RAB27A | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062052-946439a8 |
| h-12599989 | Ganglioside Rebalancing Therapy | 0.69 | 0.65 | ST3GAL2/ST8SIA1 | proposed | 2026-04-02 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| h-b490c14bf6 | CSF Soluble TREM2 Fragment Ratio as Priming State Indicator | 0.69 | 0.58 | TREM2/ADAM10/17 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062039-3b945972 |
| h-69461336 | Endothelial NRF2 Activation as a Master Switch for Post-CA BBB Protection | 0.69 | 0.49 | NRF2 (NFE2L2) in brain microvascular endothelial cells | promoted | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-174000-6451afef |
| h-d2df6eaf | Reelin-Mediated Cytoskeletal Stabilization Protocol | 0.69 | 0.50 | RELN | debated | 2026-04-02 | sda-2026-04-01-gap-004 |
| h-eea667a9 | Cross-Seeding Prevention Strategy | 0.69 | 0.68 | TARDBP | debated | 2026-04-02 | sda-2026-04-01-gap-v2-68d9c9c1 |
| h-6b84d8e2 | Hypocretin-Neurogenesis Coupling Therapy | 0.69 | 0.30 | HCRT | debated | 2026-04-02 | sda-2026-04-01-gap-v2-18cf98ca |
| h-b295a9dd | Lysosomal Positioning Dynamics Modulation | 0.69 | 0.58 | LAMP1 | debated | 2026-04-02 | sda-2026-04-01-gap-011 |
| h-f7d4cdb947 | Gamma entrainment suppresses hippocampal ERK1/2 hyperactivity to decrease AD-rel | 0.69 | 0.72 | MAPK3/MAPK1 (ERK1/2); MAP2K1/MAP2K2 (MEK1/2); RASGRF1 | proposed | 2026-04-28 | SRB-2026-04-28-h-bdbd2120 |
| h-a54ec316 | Wnt/β-catenin Pathway Restoration | 0.69 | 0.72 | CTNNB1 | proposed | 2026-04-16 | SDA-2026-04-16-gap-bbb-tjp-20260416041707 |
| h-13ef5927 | CX43 hemichannel engineering enables size-selective mitochondrial transfer | 0.69 | 0.55 | GJA1 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-89432b95 |
| h-044ee057 | TREM2 Conformational Stabilizers for Synaptic Discrimination | 0.69 | 0.50 | TREM2 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-691b42f1 |
| h-SDA-2026-04-26-gap | Plasma D-Dimer Elevation Reflects Fibrinogen Leakage and Secondary Fibrinolysis | 0.69 | 0.44 | FGA, FGB, FGG, D-dimer | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260426-002803 |
| h-SDA-2026-04-26-gap | Blood Astrocyte-Derived Exosomal AQP4 Mislocalization Predicts Early Glymphatic | 0.69 | 0.44 | AQP4 | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260426-002803 |
| h-6ed7b5c8 | TREM2-APOE Axis Manipulation via APOE Lipidation for DAM Recruitment | 0.69 | 0.78 | TREM2-APOE | proposed | 2026-04-26 | SDA-2026-04-17-gap-microglial-subtypes-pharmaco-202604170000 |
| h-31980740 | GLUT1-Mediated Glucose Flux Coefficient as Neuroprotection Indicator | 0.68 | 0.60 | SLC2A1 | proposed | 2026-04-17 | SDA-2026-04-04-gap-debate-20260403-222618-c698b06a |
| h-73e4340b | Pericyte Contractility Reset via Selective PDGFR-β Agonism | 0.68 | 0.45 | PDGFRB | debated | 2026-04-02 | sda-2026-04-01-gap-v2-ee5a5023 |
| h-37d2482d | hnRNPA2B1-Mediated Structural Remodeling Controls lncRNA-0021 Accessibility for | 0.68 | 0.30 | hnRNPA2B1, lncRNA-0021 (RBP-bound state) | proposed | 2026-04-17 | SDA-2026-04-16-gap-pubmed-20260410-150509-76c40dac |
| h-21d655104e | Focused Ultrasound with Microbubble Contrast Agents | 0.68 | 0.70 | IGFBPL1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062045-6addd0cf |
| h-analogy-aadfdd67 | FUS Phase Separation Dominance in FTD-TDP: Aberrant Condensate Hijacking of RNA | 0.68 | 0.65 | FUS | active | 2026-04-28 | |
| h-analogy-8b267076 | ISR/eIF2α~P Overflow Represses Synaptic Protein Synthesis Downstream of Tau/Aβ P | 0.68 | 0.65 | EIF2AK3 (PERK) | active | 2026-04-28 | |
| h-2698e999 | Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Assembly During Develop | 0.68 | 0.82 | SYNGAP1 | promoted | 2026-04-15 | SDA-2026-04-15-gap-pubmed-20260411-084510-fbfafe2c |
| h-2ca830cd | STMN2 Restoration as a Prerequisite for Axon Growth After TDP-43 Clearance | 0.68 | 0.78 | STMN2 | promoted | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-181356-57d1f917 |
| h-2651ca91 | Multi-Target Synergy via Presynaptic Vesicle Hub Convergence | 0.68 | 0.42 | TH, VMAT2, DAT, GCH1, BDNF, SNCA (presynaptic hub) | proposed | 2026-04-14 | SDA-2026-04-13-gap-pubmed-20260410-145531-5c4e7b59 |
| h-541d61c3 | Astrocyte-Selective APOE4 Silencing via Lipid Nanoparticles | 0.68 | 0.80 | APOE4 | promoted | 2026-04-04 | SDA-2026-04-03-gap-debate-20260403-222543-20260402 |
| h-63b7bacd | Context-Dependent CRISPR Activation in Specific Neuronal Subtypes | 0.68 | 0.60 | Cell-type-specific essential genes | proposed | 2026-04-03 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |
| h-7eaed928c5 | TREM2 Microglial Activation Rescues Amyloid Clearance in AD | 0.68 | 0.82 | TREM2 | debated | 2026-04-26 | test-hypothesis-fixtures-v1 |
| h-1073c2422d | Differential Ubiquitin Chain Topology Creates 'Invisible' Surface on Pathologica | 0.68 | 0.65 | TRIM21, G3BP1, OTUD1/OTUD7B | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041423-3a6aa4ab |
| h-ca454967 | HDAC6 Activation as SCFA-Mediated Neuroprotective Mechanism | 0.68 | 0.68 | HDAC6, HSP90AA1 | proposed | 2026-04-13 | SDA-2026-04-12-gap-debate-20260410-113021-6fbc6da4 |
| 44b404ab-eabb-45a2-a | CCL2-CCR2 Driven Macrophage Infiltration Selectively Strips Fast-Fatigable NMJs | 0.68 | 0.42 | CCL2 | open | 2026-04-28 | f7f8019f-08f6-428b-adff-85e8ea202b60 |
| h-82100428d0 | mTORC1 Reactivation as Autophagy-Senescence Divergence Point Marker | 0.68 | 0.62 | MTOR, RPTOR, RPS6KB1, TSC1, TSC2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062101-724971bc |
| h-3e7d4f97 | Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mismatch Repair Modula | 0.68 | 0.65 | MSH3, PMS1 | proposed | 2026-04-04 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |
| h-a015e80e | Flotillin-1 Stabilization Compounds | 0.68 | 0.50 | FLOT1 | proposed | 2026-04-02 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| h-be9bab57 | PGE2–EP2–cAMP–PKA Axis Displaces Pathological Microglial Memory Traces | 0.68 | 0.62 | PTGER2 (EP2) → ADCY → cAMP → PRKA (PKA) → SIRT1 | proposed | 2026-04-26 | SDA-2026-04-08-gap-debate-20260406-062033-ad87c3fb |
| h-d7924e2bc6 | Autophagy-Lysosomal Degradation of IBA1 in Stressed Microglia | 0.68 | 0.62 | LC3/P62/SQSTM1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041439-306c2cdb |
| h-420db533 | CRISPR-Mediated Mitochondrial Genome Editing for Complex I Dysfunction | 0.68 | 0.35 | MT-ND1, MT-ND4, MT-ND6 | proposed | 2026-04-04 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |
| h-f10d82a7 | NLRP3/Mitophagy Coupling Modulation | 0.68 | 0.75 | NLRP3 | promoted | 2026-04-12 | SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402 |
| h-909199b568 | TREM2 R47H variant synergizes with APOE4 to collapse microglial lipid clearance | 0.68 | 0.72 | TREM2, APOE | proposed | 2026-04-22 | SDA-2026-04-04-gap-apoe4-lipid-metabolism |
| h-c463d225 | R-Loop Resolution Enhancement Therapy | 0.68 | 0.65 | SETX | debated | 2026-04-02 | sda-2026-04-01-gap-v2-68d9c9c1 |
| h-637a53c9 | Chaperone-Mediated APOE4 Refolding Enhancement | 0.68 | 0.60 | HSPA1A, HSP90AA1, DNAJB1, FKBP5 | debated | 2026-04-02 | sda-2026-04-01-gap-010 |
| h-0dea0ed5 | Osmotic Gradient Restoration via Selective AQP1 Enhancement in Choroid Plexus | 0.68 | 0.40 | AQP1 | debated | 2026-04-02 | sda-2026-04-01-gap-v2-ee5a5023 |
| h-f71a9791 | Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution | 0.68 | 0.30 | GPR37 | debated | 2026-04-02 | sda-2026-04-01-gap-014 |
| h-81fc2e051f | Mitochondrial Quality Control Failure | 0.68 | 0.65 | PINK1, PARK2, MFN2, SIRT3 | proposed | 2026-04-28 | SDA-2026-04-28-cross-disease-synthesis |
| h-metrep-033391a0240 | NMN Adenosine Transport Enhancement for Cortical Neuron Senescence Rescue in Alz | 0.68 | 0.75 | SLC12A8,SIRT1,SRT2104,NMN,SIRT3 | proposed | 2026-04-28 | |
| h-metrep-e58337c5a06 | Dasatinib plus Quercetin Senolytic Clearance of p16Ink4a-High Neurons in Alzheim | 0.68 | 0.75 | CDKN2A,BCL2,BCL2L1,FOXO3A,AKT1,PIK3CA,HSP90AA1 | proposed | 2026-04-28 | |
| h-metrep-5d3e6f6af6c | DRP1 S616 Hyperphosphorylation and MFN2 Downregulation Create a Vicious Cycle Dr | 0.68 | 0.75 | DRP1,MFN1,MFN2,CDK5,PRKCD,PARK2,PTEN,PGC1A,OPA1 | proposed | 2026-04-28 | |
| h-metrep-e5842c76ad1 | Metabolic Checkpoint Failure in NG2+ Oligodendrocyte Progenitor Cells Drives Whi | 0.68 | 0.75 | NG2,AMPK,PRKAA1,TSC2,MTOR,RPTOR,SIRT1,CDKN2A,MBP,PLP1,OLIG1, | proposed | 2026-04-28 | |