| h-var-42a172bc53 | TREM2-Dependent Senescent Microglia Disrupt Astrocyte Communication Networks | 0.60 | 0.53 | TREM2/TYROBP | promoted | 2026-04-21 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-e9e0225d | Neurovascular Permeability Score (NVPS): Composite Plasma + Imaging Biomarker Pa | 0.60 | 0.18 | GFAP | proposed | 2026-04-26 | SDA-2026-04-26-gap-bbb-permeability-biomarker-20260426 |
| h-var-a09981fa01 | TREM2-Mediated Oligodendrocyte-Microglia Cross-talk in White Matter Neurodegener | 0.60 | 0.53 | TREM2 | proposed | 2026-04-21 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-9e4b98524b | mTORC1 Hyperactivation Impairs Autophagic Flux and Drives Senescence | 0.60 | 0.62 | MTOR/TFEB/TFE3 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-5f43216e |
| h-84be6621ea | C1Q-Mediated Defective Efferocytosis Driving Necrotic Core Expansion | 0.60 | 0.55 | C1QA/C1QC | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062122-b65f8ebc |
| h-var-223b8be521 | TREM2-Mediated Astroglial Reactivity in Neurodegeneration | 0.60 | 0.53 | TREM2 | promoted | 2026-04-21 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-3a5aefe1e4 | Displacement of G3BP1 RGG Box from Target RNA via Ubiquitin-Mediated Allostery | 0.60 | 0.65 | G3BP1 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041423-2d1db50c |
| h-aa7eae0c3a | Cytosolic TDP-43 aggregation sequesters SNAP29 and syntaxin-17, blocking autopha | 0.60 | 0.65 | TARDBP | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062212-6777e5dd |
| h-af85b48c8e | TNF-α–C1r/C1s Bridge Between NF-κB and Classical Complement Cascade | 0.60 | 0.48 | TNF; TNFRSF1A; C1R; C1S | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062128-afe67892 |
| h-5f98d0e5d4 | APOE4 Induces Region-Specific Microglial Senescence Driving Frontal Cortex Neuro | 0.60 | 0.65 | APOE4 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-ec89b1e4 |
| ea26a0a6-f96e-4918-9 | Manual uptake test | 0.60 | 0.37 | | proposed | 2026-04-27 | |
| h-6a6f132a50e9 | Activity-dependent MAP6 scaffolding at synapses | 0.60 | 0.60 | MAP6 | proposed | 2026-04-25 | |
| h-SDA-2026-04-26-gap | Elevated Circulating sPDGFRβ Reflects Early Pericyte Loss Preceding Neurodegener | 0.60 | 0.34 | PDGFRB | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260426-001521 |
| h-30afe4733d | TDP-43 LLPS and proteostasis dysregulation in ALS/FTD | 0.60 | 0.70 | TARDBP | proposed | 2026-04-29 | SDA-2026-04-29-gap-test-20260425-224949 |
| h-2c11c690e8 | H4: Hyperconnected Hub Status Creates Proteostatic Traffic Jams | 0.60 | 0.58 | ERN1 (IRE1α), TFG, ATG9A | proposed | 2026-04-22 | SDA-2026-04-02-gap-ec-layer2-vulnerability |
| h-f8316acf | Differential Interneuron Optogenetic Restoration Therapy | 0.60 | 0.70 | PVALB/SST | proposed | 2026-04-04 | SDA-2026-04-03-26abc5e5f9f2 |
| h-d16c2411 | Oligodendrocyte-Targeted Myelin Sulfatide Restoration Therapy | 0.60 | 0.60 | CST, GAL3ST1 | proposed | 2026-04-04 | SDA-2026-04-03-gap-debate-20260403-222543-20260402 |
| h-0ca9a295f6 | Rutin enhances chaperone and autophagic clearance of misfolded tau | 0.60 | 0.49 | SQSTM1 | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260411-085530-9015d285-debate |
| h_seaad_004 | OPC differentiation blockade contributes to white matter degeneration in early-s | 0.60 | 0.71 | PDGFRA | proposed | 2026-04-04 | SDA-2026-04-04-analysis_sea_ad_001 |
| h-827a821b | Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Circuits | 0.60 | 0.40 | PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes | proposed | 2026-04-02 | SDA-2026-04-03-gap-crispr-neurodegeneration-20260402 |
| h-5744614d14 | HSF1 reprioritizes transcription and suppresses MAPT while restoring proteostasi | 0.60 | 0.52 | HSF1 | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260411-083749-7d0cea3d-debate |
| h-423b50a1 | Aryl Hydrocarbon Receptor (AhR) Activation by Microbiome Metabolites Promotes A2 | 0.60 | 0.58 | AHR, CYP1A1, NFKB1, IL6 | promoted | 2026-04-14 | SDA-2026-04-14-gap-pubmed-20260410-183021-c13d9f04 |
| h-54b9e0f5 | Glycosaminoglycan Template Disruption Approach | 0.60 | 0.65 | HSPG2 | proposed | 2026-04-02 | SDA-2026-04-01-gap-9137255b |
| h-fc7311c6be | C9orf72 Nucleocytoplasmic Transport Rescue for ALS/FTD | 0.60 | 0.60 | C9orf72 | proposed | 2026-05-06 | SDA-2026-05-06-gap-test-20260425-224949 |
| h-c8d2ea20 | Selective C1q-CRP vs. C1q-IgG Axis Inhibition | 0.60 | 0.55 | C1QA/C1QB/C1QC, CRP, FCGR1A | promoted | 2026-04-16 | SDA-2026-04-16-gap-pubmed-20260410-095709-4e97c09e |
| h-075f1f02 | Brain Insulin Resistance with Glucose Transporter Dysfunction | 0.60 | 0.50 | GLUT3/GLUT4 | proposed | 2026-04-02 | SDA-2026-04-02-gap-v2-5d0e3052 |
| h-var-9da3ee8550 | Closed-loop tACS targeting EC-II PV interneurons to enhance perisomatic inhibiti | 0.60 | 0.72 | PVALB | promoted | 2026-04-07 | SDA-2026-04-03-26abc5e5f9f2 |
| h-793f9f273d | Temporal Decoupling of CSF p-tau217 Normalization from Amyloid PET Negativity Cr | 0.59 | 0.58 | NA - Biomarker validation hypothesis | proposed | 2026-04-25 | |
| h-57e8f4db75 | Aβ-induced downregulation of circPDS5B derepresses TDP-43 mRNA translation in li | 0.59 | 0.50 | circPDS5B (hsa_circ_0083342) / TARDBP | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062202-094b44bf |
| h-1dc6387ca9 | Exosomal α-Synuclein as an Interneuronal Propagation Vector in Parkinson's Disea | 0.59 | 0.75 | RAB27A | proposed | 2026-04-26 | legacy-pre-pipeline-import-v1 |
| h-3c73c503dd | Aβ42 oligomers drive TDP-43 phosphorylation at s409/410 through CDK5/p25 activat | 0.59 | 0.62 | CDK5R1 (p25 regulatory subunit) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062202-094b44bf |
| h-05b8894a | Netrin-1 Gradient Restoration | 0.59 | 0.20 | NTN1 | debated | 2026-04-02 | sda-2026-04-01-gap-005 |
| h-18a0fcc6 | VCP-Mediated Autophagy Enhancement | 0.59 | 0.49 | VCP | archived | 2026-04-02 | SDA-2026-04-04-gap-tau-prop-20260402003221 |
| h-822ed52f | GFAP Perivascular Redistribution (End-Feet Retraction) as True BBB Dysfunction B | 0.59 | 0.18 | GFAP | proposed | 2026-04-26 | SDA-2026-04-26-gap-bbb-permeability-biomarker-20260426 |
| h-0636e675 | NAMPT-SIRT1 Axis as Master Regulator of SASP-Dependent Complement Amplification | 0.59 | 0.60 | NAMPT, SIRT1 | promoted | 2026-04-16 | SDA-2026-04-16-gap-20260416-133111 |
| h-gwas-ptk2b-endocyt | Tau-trafficking GWAS loci define a druggable PTK2B endocytosis-kinase axis in AD | 0.59 | 0.58 | PTK2B/BIN1/PICALM | proposed | 2026-04-26 | |
| h-1179b3cc89 | Stratified falsifiers should govern AD Master Plan preregistration: BDNF | 0.59 | 0.54 | AD | proposed | 2026-04-28 | AD-MASTER-PLAN-BDNF-20260428030755 |
| h-2648ab06ce | Stratified falsifiers should govern Methodology challenge: notebook 'Astrocyte r | 0.59 | 0.54 | challenge | proposed | 2026-04-28 | SDA-2026-04-27-gap-methodol-20260427-035148-9ab1842d |
| h-aba0219737 | Stratified falsifiers should govern Methodology challenge: notebook 'Mitochondri | 0.59 | 0.54 | challenge | proposed | 2026-04-28 | SDA-2026-04-28-gap-methodol-20260427-035148-7b3b3df4 |
| h-d3e7e3dd | TREM2-C1Q Competitive Binding to Prevent Complement-Mediated Cholinergic Synapse | 0.59 | 0.60 | TREM2,C1Q | proposed | 2026-04-16 | SDA-2026-04-16-gap-pubmed-20260411-082446-2c1c9e2d |
| h-f8bd14f311 | Stratified falsifiers should govern AD Master Plan preregistration: TREM2 | 0.59 | 0.54 | AD | proposed | 2026-04-28 | AD-MASTER-PLAN-TREM2-20260428030753 |
| h-1664ae69a6 | Stratified falsifiers should govern Microglial Priming as Upstream Causal Node A | 0.59 | 0.54 | CX3CR1 | proposed | 2026-04-28 | SDA-2026-04-28-microglial-priming-causal-nd |
| h-b6c9f53f86 | Stratified falsifiers should govern Causal Discovery Benchmark: SciDEX vs LLM Ba | 0.59 | 0.54 | causal discovery | proposed | 2026-04-28 | SDA-causal-benchmark-20260428-035713 |
| h-87b29d2a9d | Stratified falsifiers should govern Methodology challenge: notebook 'Mitochondri | 0.59 | 0.54 | challenge | proposed | 2026-04-28 | SDA-2026-04-27-gap-methodol-20260427-035148-7b3b3df4 |
| h-87754d6a4a | Stratified falsifiers should govern AD Master Plan preregistration: GFAP | 0.59 | 0.54 | AD | proposed | 2026-04-28 | AD-MASTER-PLAN-GFAP-20260428030756 |
| h-9ba0d309d9 | Stratified falsifiers should govern AD Master Plan preregistration: APOE | 0.59 | 0.54 | AD | proposed | 2026-04-28 | AD-MASTER-PLAN-APOE-20260428030754 |
| h-d3b4afec85 | Stratified falsifiers should govern AD Master Plan preregistration: LRP1 | 0.59 | 0.54 | AD | proposed | 2026-04-28 | AD-MASTER-PLAN-LRP1-20260428030757 |
| h-0516c501 | TFEB Activation to Restore Lysosomal Biogenesis in Aged Synapses | 0.59 | 0.57 | TFEB (TFE3, TFE4 family) | proposed | 2026-04-25 | SDA-2026-04-16-frontier-proteomics-1c3dba72 |
| h-01eb4f1d71 | MALAT1 Three-Way Junction as a Druggable Target for Structure-Selective ASOs | 0.59 | 0.58 | MALAT1 | proposed | 2026-04-21 | SDA-2026-04-10-gap-debate-20260410-075007-232fbf62 |
| h-be57524c3c | Neuronal MHC Class I Expression as a Selectivity Determinant | 0.59 | 0.58 | H2-Kb (H2-K1), Lilrb4 (LilrB2) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062128-c84a87d9 |