| h-b6af8aa071 | Microglial Priming via NF-κB-Dependent DAM Phenotype and Complement Biosynthesis | 0.58 | 0.55 | NFKB1; IKBKB; C1QA; C3 | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062128-afe67892 |
| h-e744d98ee1 | LAMP-2 replacement therapy prevents lysosomal membrane permeabilization and down | 0.58 | 0.55 | LAMP2 (LGMN) | proposed | 2026-04-22 | SDA-2026-04-04-gap-lysosomal-cathepsin-ad |
| h-d3a2216a86 | Female Microglia Exhibit Reduced P2Y12 Expression Conferring Neuroprotection Thr | 0.58 | 0.58 | P2RY12 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041439-ec89b1e4 |
| h-c42d677719 | A lower trazodone dose of 50-100 mg nightly may be sufficient only in dementia p | 0.58 | 0.45 | HTR2A; HRH1; AQP4 | proposed | 2026-04-25 | |
| h-c1828e7264 | Neuroinflammation-Driven TDP-43 Mislocalization via Microglial APOE4 Signaling | 0.58 | 0.52 | NLRP3, LRP1, IL1B, TNF | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062202-c8c5a9a1 |
| h-07691d28 | Oxygen Pressure-Dependent BDNF Cascade: DHHC2/PSD95 Stabilization for Synaptic R | 0.58 | 0.64 | | proposed | 2026-04-17 | SDA-2026-04-26-gap-pubmed-20260410-181340-8acb24dc-debate |
| h-f7db2634ee | LXR Agonism (H4): Microglial Lipid Efflux Promotion | 0.58 | 0.62 | NR1H3 (LXRα/NR1H3) | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-180918-962b1ada-debate |
| h-81bb99f5b9 | H7: Dual-Target Strategy (Senolytics + APOE4→3 Conversion) | 0.58 | 0.58 | APOE; CDKN2A | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-5d7b9dc0 |
| h-0fcf8ff993 | H5: Complement Dysregulation Drives Synapse Loss via Senescent APOE4 Astrocytes | 0.58 | 0.55 | C3; C3AR1; C5AR1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062101-5d7b9dc0 |
| h-494ad6afe0 | Nuclear Export Deficits Increase Cytosolic TDP-43 Burden | 0.58 | 0.55 | XPO1/CRM1, ALYREF, THOC1/THOC2, TDP-43 NLS | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062141-611cf046 |
| h-3cdc8defe3 | Limited Calcium Release Without Sufficient Cathepsin Efflux | 0.58 | 0.55 | TRPML1/MCOLN1, Calcineurin/NFAT | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062150-a6cc7467 |
| h-cf3596a8f7 | Selective c-Abl Inhibition Promotes α-Synuclein Clearance via Autophagy | 0.58 | 0.68 | ABL1/c-Abl | proposed | 2026-04-26 | test-hypothesis-fixtures-v1 |
| h-6a4c716402 | TREM2-Driven Phagocytic Receptor Cascades Determine Mitochondrial Antigen Presen | 0.58 | 0.48 | TREM2 | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-062132-5d93ddb2 |
| h-16818f9bf1 | APOE4 Structural Correction by Small Molecule Correctors | 0.58 | 0.55 | APOE4 | proposed | 2026-04-22 | SDA-2026-04-02-gap-apoe4-targeting |
| h-5559a65b3f | Liproxstatin-1 as Mechanism-Validation Tool for Ferroptosis Inhibition | 0.58 | 0.65 | ALOX12/15 (12/15-lipoxygenase) / HDAC4 axis | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-174000-6451afef-debate |
| h-9f504f5d4d | Astrocyte cGAS/STING Activation Converts Protective into Destructive Neuroinflam | 0.58 | 0.55 | STING (TMEM173) in astrocytes (GFAP+ cells) | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062141-fc60e018 |
| h-a1f87d1fd6 | APOE4 drives astrocyte metabolic reprogramming toward glycolysis via PGC-1α supp | 0.58 | 0.58 | PPARGC1A (PGC-1α), SIRT1, SREBF1 (SREBP1c) | proposed | 2026-04-22 | SDA-2026-04-04-gap-apoe4-lipid-metabolism |
| h-d645402b | ALOX15 Inhibition Combined with Selenium Augmentation for Synergistic Ferroptosi | 0.58 | 0.58 | ALOX15, SELENOP | proposed | 2026-04-16 | SDA-2026-04-16-gap-ferroptosis-als-d2fb6bf796ed |
| h-47e3c2965c | AQP4 Missorting in Reactive Astrocytes Drives Glymphatic Failure in Chronic Neur | 0.58 | 0.55 | AQP4; STAT3; MMP9 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-ce0abc1e |
| h-684a2fffb5 | Dysregulated G3BP1 Signaling Impairs Local Translation in Neuronal Processes, Co | 0.58 | 0.55 | G3BP1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041428-e14e6524 |
| h-6f274df61e | Disrupted AQP4-Mediated K+ Spatial Buffering Causes Neuronal Hyperexcitability a | 0.58 | 0.58 | AQP4; KCNJ10 (Kir4.1); ATP1A2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-041445-ce0abc1e |
| h-d0099a1106 | Structure-interacting small molecules that stabilize the APOE4 molten globule do | 0.58 | 0.55 | APOE (protein structure stabilizer) | proposed | 2026-04-22 | SDA-2026-04-04-gap-apoe4-lipid-metabolism |
| h-6358a464ac | αvβ3 Integrin-FAK-SYK-CARD9/NF-κB Pathway | 0.58 | 0.68 | ITGAV/ITGB3 (αvβ3 heterodimer), PTK2 (FAK), SYK, CARD9 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-062118-e3613755 |
| h-85bc154b49 | TFEB Nuclear Translocation Clears α-Synuclein via Autophagy-Lysosome Pathway | 0.58 | 0.62 | TFEB (MLST8) | proposed | 2026-04-28 | SDA-TEST-PREREG-003 |
| h-1431a507bf | Gut Bacterial Metabolite-AhR Dysregulation Converts SCFA-Deficiency into IDO1-Dr | 0.58 | 0.65 | AHR, IDO1, KYNU, HAAO, GRIN2A, STAT3 | proposed | 2026-04-26 | SDA-2026-04-26-gap-20260425-225305 |
| h-762a78d0af | RNA Metabolism and Nucleocytoplasmic Transport Defects | 0.58 | 0.62 | RanGAP1, NUP205, C9orf72, FUS | proposed | 2026-04-28 | SDA-2026-04-28-cross-disease-synthesis |
| h-f19b8ac8 | Complement-Mediated Synaptic Protection | 0.58 | 0.40 | C1QA | debated | 2026-04-04 | SDA-2026-04-04-gap-20260404-microglial-priming-early-ad |
| h-45d23b07 | Multi-Biomarker Composite Index Surpassing Amyloid PET for Treatment Response Pr | 0.58 | 0.45 | COMPOSITE_BIOMARKER | promoted | 2026-04-16 | SDA-BIOMNI-BIOMARKE-34ec007c |
| h-6880f29b | IGFBPL1-Mediated Microglial Reprogramming | 0.58 | 0.40 | IGFBPL1 | debated | 2026-04-04 | SDA-2026-04-04-gap-20260404-microglial-priming-early-ad |
| h-var-fe8899ff37 | TREM2-Astrocyte Communication in Microglial Dysfunction | 0.58 | 0.53 | TREM2 | promoted | 2026-04-21 | SDA-2026-04-03-gap-aging-mouse-brain-v3-20260402 |
| h-0bdc3803 | Spatial Transcriptome-Guided Precision Cell Therapy | 0.58 | 0.55 | SOX10 and DLX1/2 | proposed | 2026-04-04 | SDA-2026-04-03-gap-seaad-v2-20260402032945 |
| h-8e3748fe5c | Chronic mTORC1-ULK1 signaling blocks autophagy initiation in irradiated pericyte | 0.58 | 0.49 | MTOR | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-193006-9525a13b-debate |
| h-fbc439901e | NAD+/SARM1 Axis Provides Metabolic Feedback Coupling Mitophagy to ER-Phagy | 0.58 | 0.52 | SARM1 (SARM1), PARP1, SIRT1, SIRT3 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062132-e71b3ef7 |
| h-73e29e3a | Synaptic Vesicle Tau Capture Inhibition | 0.58 | 0.34 | SNAP25 | archived | 2026-04-02 | SDA-2026-04-04-gap-tau-prop-20260402003221 |
| h-b6167641 | TDP-43 Cryptic Exon–Targeted ASOs to Restore Hippocampal Gamma Oscillations | 0.58 | 0.55 | TARDBP (TDP-43) / cryptic splice sites in GABAergic transcri | promoted | 2026-04-13 | SDA-2026-04-13-gap-20260410-172514 |
| h-7c80747e | Hepcidin-Iron Set Point Hypothesis | 0.58 | 0.55 | | proposed | 2026-04-13 | SDA-2026-04-13-gap-pubmed-20260410-155308-2c6815fb |
| h-var-0dd032612f | Dynamic Microglial Phenotype Switching Biomarker Panel for Neuroinflammatory Tre | 0.58 | 0.42 | TREM2 | promoted | 2026-04-20 | SDA-2026-04-16-gap-pubmed-20260410-192526-f2bbb9ab |
| h-4c10f3df93 | TBK1 Phosphorylation State Creates Phospho-Regulated Peripheral Retention Thresh | 0.58 | 0.50 | TBK1 | proposed | 2026-04-21 | SDA-2026-04-08-gap-pubmed-20260406-041423-9c2c2ee3 |
| h-9a9ad9ae54 | microglial priming across neurodegenerative diseases should remain under review | 0.58 | 0.52 | C1QA | proposed | 2026-04-28 | SDA-2026-04-28-microglial-priming-causal-nd |
| h-f12d206863 | APOE should remain under review until replicated | 0.58 | 0.52 | tau | proposed | 2026-04-28 | AD-MASTER-PLAN-APOE-20260428030754 |
| h-d6c8b66717 | GFAP should remain under review until replicated | 0.58 | 0.52 | tau | proposed | 2026-04-28 | AD-MASTER-PLAN-GFAP-20260428030756 |
| h-c092c61024 | LRP1 should remain under review until replicated | 0.58 | 0.52 | tau | proposed | 2026-04-28 | AD-MASTER-PLAN-LRP1-20260428030757 |
| h-7204d85a33 | Mitochondrial transfer between neurons and glia — Rich Analysis Notebook should | 0.58 | 0.52 | Mitochondrial | proposed | 2026-04-28 | SDA-2026-04-28-gap-methodol-20260427-035148-7b3b3df4 |
| h-d773e0bf21 | H4: Age-Related Hsp70 Chaperone Decline Blocks Granule Reversibility | 0.58 | 0.58 | HSPA1A/HSPA1B, DNAJB6, DNAJB8 | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-041428-4c4414ad |
| h-50249eb28d | Mitochondrial transfer between neurons and glia — Rich Analysis Notebook should | 0.58 | 0.52 | Mitochondrial | proposed | 2026-04-28 | SDA-2026-04-27-gap-methodol-20260427-035148-7b3b3df4 |
| h-0452017800 | SciDEX debate-engine causal discovery benchmark should remain under review until | 0.58 | 0.52 | calibration | proposed | 2026-04-28 | SDA-causal-benchmark-20260428-035713 |
| h-bfcbb20cff | TREM2 should remain under review until replicated | 0.58 | 0.52 | tau | proposed | 2026-04-28 | AD-MASTER-PLAN-TREM2-20260428030753 |
| h-665d562cbf | Astrocyte reactivity subtypes in neurodegeneration — Rich Analysis Notebook shou | 0.58 | 0.52 | Astrocyte | proposed | 2026-04-28 | SDA-2026-04-27-gap-methodol-20260427-035148-9ab1842d |
| h-1cfdb2339d | BDNF should remain under review until replicated | 0.58 | 0.52 | tau | proposed | 2026-04-28 | AD-MASTER-PLAN-BDNF-20260428030755 |
| h-dc505f6346 | TREM2 Promoter Silencing via DNA Hypermethylation | 0.58 | 0.68 | TREM2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062045-56983337 |