| h-cross-synth-tbk1-o | TBK1-OPTN-p62 selective autophagy failure across ALS, FTD, and PD-like proteotox | 0.78 | 0.73 | TBK1 | active | 2026-04-28 | SDA-2026-04-28-cross-disease-synthesis |
| h-62f9fc90 | Prefrontal sensory gating circuit restoration via PV interneuron enhancement | 0.78 | 0.75 | PVALB | promoted | 2026-04-02 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-787aa9d1b4 | Alpha-gamma cross-frequency coupling enhancement to restore thalamo-cortical mem | 0.77 | 0.78 | SST | promoted | 2026-04-12 | SDA-2026-04-03-26abc5e5f9f2 |
| h-var-8412ce00a4 | Dual-Circuit Tau Vulnerability Cascade | 0.77 | 0.75 | MAPT | promoted | 2026-04-07 | SDA-2026-04-03-26abc5e5f9f2 |
| h-trem2-f48baa0c | TREM2-APOE4 Co-targeting — Simultaneous Correction of Lipid Sensing and Clearanc | 0.77 | 0.67 | TREM2, APOE | proposed | 2026-04-04 | SDA-2026-04-02-gap-001 |
| h-cd60e2ec | Thalamocortical Synchrony Restoration via NMDA Modulation | 0.77 | 0.60 | GRIN2B | proposed | 2026-04-04 | SDA-2026-04-03-26abc5e5f9f2 |
| h-23a3cc07 | Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modulation | 0.77 | 0.30 | FCGRT | promoted | 2026-04-02 | sda-2026-04-01-gap-008 |
| h-b98ff29728 | Gamma entrainment induces activity-dependent BDNF release to rescue NMJ and dend | 0.77 | 0.78 | BDNF (brain-derived neurotrophic factor); NTRK2 (TrkB); CREB | proposed | 2026-04-28 | SRB-2026-04-28-h-bdbd2120 |
| h-var-97b18b880d | ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE Peroxidat | 0.77 | 0.82 | ALOX15 | debated | 2026-04-05 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| h-89f1963f | Hypothesis 2: GPNMB-CD44 Axis as Anti-inflammatory Pathway | 0.77 | 0.42 | GPNMB, CD44 | proposed | 2026-04-17 | SDA-2026-04-26-gap-pubmed-20260410-170057-a2f72fd8-debate |
| h-c1d5dcbf48 | TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle Autophagy | 0.77 | 0.78 | TBK1, OPTN (TBC1D7), NDP52/CALCOCO2 | proposed | 2026-04-21 | SDA-2026-04-07-gap-pubmed-20260406-062132-e71b3ef7 |
| h-c58ac188fc | Enhancing Microglial Phagocytosis of Extracellular Tau via TREM2 Activation | 0.77 | 0.82 | TREM2 | debated | 2026-04-22 | SDA-2026-04-04-gap-tau-prion-spreading |
| h-eb7e85343b | H3: SIRT1 Insufficiency Disconnects Metabolic Sensing from Epigenomic Homeostasi | 0.77 | 0.78 | SIRT1, NAMPT, NAD+ salvage pathway | proposed | 2026-04-22 | SDA-2026-04-04-gap-20260404-120802 |
| h-bc351274 | METTL3-Mediated m6A Modification of lncRNA-0021 Regulates miR-6361 Sequestration | 0.77 | 0.35 | METTL3, YTHDF2, lncRNA-0021 (m6A-modified) | proposed | 2026-04-17 | SDA-2026-04-26-gap-pubmed-20260410-150509-76c40dac-debate |
| hyp-SDA-2026-04-12-2 | Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Cholinergic Signaling | 0.77 | 0.65 | CHRNA7, CHRM1 | debated | 2026-04-12 | SDA-2026-04-12-20260411-082446-2c1c9e2d |
| SDA-2026-04-16-hyp-b | Oligodendrocyte Precursor Cell Senescence in White Matter Disease | 0.77 | 0.60 | CSPG4,OLIG2,BCL2 | proposed | 2026-04-16 | SDA-2026-04-04-gap-senescent-clearance-neuro |
| h-af0ec8d843 | Complement C1q-Mediated Synaptic Pruning Drives Early Cognitive Decline in Alzhe | 0.77 | 0.82 | C1Q | proposed | 2026-04-26 | legacy-pre-pipeline-import-v1 |
| h-94ae1e45a0 | p21^Cip1 Phospho-State as Autophagy Responsiveness Predictor | 0.77 | 0.68 | CDKN1A, CDK4, CDK6, ATM, PPP1CA | proposed | 2026-04-21 | SDA-2026-04-07-gap-debate-20260406-062101-724971bc |
| h-addc0a61 | Chromatin Accessibility Restoration via BRD4 Modulation | 0.77 | 0.60 | BRD4 | promoted | 2026-04-02 | SDA-2026-04-04-gap-epigenetic-reprog-b685190e |
| h-2600483e | CYP46A1 Overexpression Gene Therapy | 0.77 | 0.85 | CYP46A1 | promoted | 2026-04-02 | SDA-2026-04-01-gap-lipid-rafts-2026-04-01 |
| h-811520b92f | AAV-PHP.eB-Mediated Microglial IGFBPL1 Expression | 0.77 | 0.72 | IGFBPL1 | proposed | 2026-04-22 | SDA-2026-04-06-gap-debate-20260406-062045-6addd0cf |
| h-25580e2e | Lysosomal Cathepsin-Dependent Tau Clearance | 0.77 | 0.45 | | proposed | 2026-04-17 | SDA-2026-04-26-gap-pubmed-20260410-150544-e3a2eab9-debate |
| h-var-ea70ada256 | Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla | 0.77 | 0.78 | SST | proposed | 2026-04-12 | SDA-2026-04-03-26abc5e5f9f2 |
| h-ed8dee29 | HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA Prevention | 0.77 | 0.62 | ABCA1 | proposed | 2026-04-15 | SDA-2026-04-15-gap-pubmed-20260411-083043-759b4c5e |
| h-44195347 | APOE4 Allosteric Rescue via Small Molecule Chaperones | 0.76 | 0.40 | APOE | debated | 2026-04-02 | sda-2026-04-01-gap-010 |
| h-var-a09491064e | Chromatin Remodeling-Mediated Nutrient Sensing Restoration | 0.76 | 0.82 | SMARCA4 | promoted | 2026-04-12 | SDA-2026-04-04-gap-epigenetic-reprog-b685190e |
| h-var-70a95f9d57 | LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability in Diseas | 0.76 | 0.82 | LPCAT3 | debated | 2026-04-05 | SDA-2026-04-03-gap-seaad-v4-20260402065846 |
| h-3f4cb83e0c | Selective LXRβ agonists restore ABCA1/ABCG1 expression and APOE lipidation in AP | 0.76 | 0.78 | NR1H2 (LXRβ), ABCA1, ABCG1 | proposed | 2026-04-22 | SDA-2026-04-04-gap-apoe4-lipid-metabolism |
| h-1acdd55e | SASP-Mediated Cholinergic Synapse Disruption | 0.76 | 0.50 | MMP2/MMP9 | promoted | 2026-04-02 | sda-2026-04-01-gap-013 |
| h-b7898b79 | Circadian Clock-Autophagy Synchronization | 0.76 | 0.70 | CLOCK | debated | 2026-04-02 | sda-2026-04-01-gap-v2-18cf98ca |
| h-013cc31a80 | Focused Ultrasound with Microbubble Contrast Agents for Antibody CNS Delivery | 0.76 | 0.81 | CLDN5/ZO-1 tight junction complex; KDR/VEGFR2 | proposed | 2026-04-22 | SDA-2026-04-02-gap-bbb-antibody-transport |
| h-15cf5802 | Hypothesis 3: HepaCAM-Containing Extracellular Vesicles | 0.76 | 0.48 | HEPACAM1, HEPACAM2 | proposed | 2026-04-17 | SDA-2026-04-26-gap-pubmed-20260410-170057-a2f72fd8-debate |
| h-adfcd3f146 | TREM2 Crosstalk and Synergistic Activation of Phagocytic Transcriptome | 0.76 | 0.72 | TREM2/DAP12 (TYROBP) | proposed | 2026-04-22 | SDA-2026-04-06-gap-pubmed-20260406-062118-e3613755 |
| h-bcbc70473b | GluN2B-CX3CL1 Axis Controls Microglial Tau Phagocytosis | 0.76 | 0.72 | GRIN2B → CX3CL1 → CX3CR1/TREM2 axis | proposed | 2026-04-28 | SRB-2026-04-28-h-var-e2b5a7e7db |
| h-seaad-51323624 | Cell-Type Specific TREM2 Upregulation in DAM Microglia | 0.76 | 0.75 | TREM2 | promoted | 2026-04-02 | analysis-SEAAD-20260402 |
| h-var-f687d4593b | Cholinergic Basal Forebrain-Hippocampal Circuit Protection | 0.76 | 0.75 | MAPT | promoted | 2026-04-07 | SDA-2026-04-03-26abc5e5f9f2 |
| h-5bf21d2f04 | N-acetylcysteine (NAC) / System Xc⁻ - Mediated GSH Support for Neurovascular Uni | 0.76 | 0.72 | SLC7A11 (system Xc⁻) / GSH metabolism | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-174000-6451afef-debate |
| h-a71a05806a | TDP-43 Proteinopathy as a Cross-Disease Pathological Substrate | 0.76 | 0.75 | TARDBP, TIA1, UBQLN2, CHCHD10 | proposed | 2026-04-28 | SDA-2026-04-28-cross-disease-synthesis |
| h-0ac2771e1c | cGAS-STING Pathway Hyperactivation Mediates Tau Propagation | 0.76 | 0.76 | cGAS (CGAS), STING (TMEM173) | proposed | 2026-04-22 | SDA-2026-04-02-gap-2026-04-01-gap-006 |
| h-e59df37bd0 | PARP1-NAD+-AIF bioenergetic collapse drives a self-amplifying parthanatos loop | 0.76 | 0.80 | PARP1; AIFM1; NAMPT; NMNAT1/2/3 | proposed | 2026-04-25 | SDA-2026-04-26-gap-pubmed-20260410-181140-0af1a353-debate |
| h-c56d4f6a1a | ASO-mediated reduction of toxic C9orf72 dipeptide repeat proteins in ALS/FTD | 0.76 | 0.88 | C9orf72 | proposed | 2026-05-01 | SDA-2026-05-01-gap-test-20260425-224949 |
| h-3f9740bfa5 | Synaptic Vesicle Cycle Hijacking: Shared Convergent Mechanism for α-Synuclein (P | 0.76 | 0.70 | SNCA,MAPT,SNAP25,DNM1,VAMP2,CAV1 | proposed | 2026-04-27 | |
| h-3487bc5fb2 | GBA1/GCase restoration to reduce alpha-synuclein pathology in Parkinson's diseas | 0.76 | 0.86 | GBA1 | proposed | 2026-04-29 | SDA-2026-04-29-gap-test-20260425-224949 |
| h-3ab2bff6a46b | Repeat-domain exposure defines seed-competent tau conformers | 0.76 | 0.73 | MAPT | proposed | 2026-04-26 | SDA-2026-04-26-gap-debate-20260412-094623-bb7e1c4f |
| ec8b839c-6440-45dc-a | STMN2 Cryptic Exon Inclusion is the Earliest Loss-of-Function Marker of TDP-43 N | 0.76 | 0.60 | TARDBP | open | 2026-04-27 | 0ed3c364-07fd-4620-8e90-8bd33c14e370 |
| h-a20e0cbb | Targeted APOE4-to-APOE3 Base Editing Therapy | 0.76 | 0.30 | APOE | debated | 2026-04-02 | sda-2026-04-01-gap-010 |
| h-665660604fa7 | Night-phase orexin receptor antagonism rescues AD by restoring sleep-dependent c | 0.76 | 0.73 | HCRTR2 | proposed | 2026-04-26 | SDA-2026-04-26-gap-pubmed-20260410-184240-f72e77ae |
| h-39148342 | INPP5D (SHIP1) Inhibition to Shift Microglial Polarization | 0.76 | 0.38 | INPP5D | proposed | 2026-04-16 | SDA-2026-04-01-gap-001 |
| h-bc8867b7ad | APOE4 astrocytes exhibit impaired cholesterol efflux via ABCA1/ABCG1 transporter | 0.76 | 0.33 | ABCA1, ABCG1 | proposed | 2026-04-22 | SDA-2026-04-04-gap-apoe4-lipid-metabolism |
| h-862600b1 | sTREM2 as Biomarker of Cystatin-C Therapeutic Efficacy | 0.76 | 0.58 | TREM2 | proposed | 2026-04-17 | SDA-2026-04-26-gap-pubmed-20260410-150544-e3a2eab9-debate |