| Gene Symbol | blood |
| Sample Size | 4,018 whole-genome sequencing (WGS) data of blood samples |
| Cohorts | Two independent PD cohorts for validation |
| Analytical Pipeline | Kraken 2 and Bracken software with PlusPF database for microbial annotation |
| Validation | Population-based cross-cohort filtration process with resampling validation |
| Motor dysfunction | Specific bacterial species showed association with motor symptom severity |
| Cognitive impairment | Certain signatures correlated with cognitive decline in PD patients |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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