| Gene Symbol | HSPA1A |
| Full Name | Heat Shock 70 kDa Protein 1A (Hsp70-1A) |
| Aliases | HSP70-1A, HSP70, Hsp70 |
| Protein Family | Hsp70 family |
| Protein Type | Chaperone |
| Target Class | Chaperone |
| Function | Small molecule activators or allosteric modulators of chaperone function |
| Mechanism of Action | Small molecule activators or allosteric modulators of chaperone function |
| Subcellular Localization | Cytoplasm, Nucleus, Cell membrane |
| Druggability | Medium (0.46) |
| Clinical Stage | Phase III |
| Molecular Weight | ~70 kDa |
| Pathways | Akt, Chaperone, ERK/JNK Pathway, Erk/Jnk Pathway, Lipid Metabolism |
| UniProt ID | P0DMV8 |
| GeneCards | HSPA1A |
| Human Protein Atlas | HSPA1A |
| Associated Diseases | AD, AGE_RELATED_DISEASES, ALI, ALS, ALZHEIMER, AMI |
| Known Drugs/Compounds | KNK437, Trna, RN5S |
| Interactions | HSP90AA1, DNAJB1, FKBP5, SNCA, DNMT1, DUSP1 |
| SciDEX Target | View Target Profile (6 clinical trials) |
| SciDEX Hypotheses | Heat Shock Protein 70 Disaggregase Amplification Proteostasis Enhancement via APOE Chaperone Target |
| KG Connections | 924 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |