| Gene Symbol | ent-gene-8c4b5215 |
| Chromosome | 17q21.31 |
| Function | - Phosphorylation: Multiple sites (Ser13, Ser34, Thr7) affect filament assembly and turnover |
| NF-κB | Major regulator of astrocyte reactivity |
| STAT3 | Central to astrocyte responses in injury |
| AP-1 | Modulates GFAP expression in response to cytokines |
| Sp1 | Constitutive expression in healthy astrocytes |
| Phosphorylation | Multiple sites (Ser13, Ser34, Thr7) affect filament assembly and turnover |
| Citrinination | Associated with astrocyte activation states |
| Oxidation | Modification in oxidative stress conditions |
| Proteolytic cleavage | Produces fragments detectable in disease states |
| PD vs. Controls | Elevated CSF and blood GFAP in PD patients |
| PD Progression | GFAP levels correlate with disease severity (UPDRS scores) |
| Astrocyte Reactivity | Reflects neuroinflammation in substantia nigra |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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