| Gene Symbol | ent-gene-8c4b5215 |
| AD vs. FTD | GFAP higher in AD[@verber2024] |
| AD vs. PD | GFAP significantly elevated in AD |
| AD vs. Lewy body dementia | Mixed results, overlapping values |
| GFAP | Reflects inflammatory response |
| NfL | Neuronal injury, rises later in disease |
| Combined | Improved diagnostic accuracy, progression prediction[@arianna2024] |
| p-Tau | Reflects tau pathology directly |
| Complementary | Different biological pathways |
| Advantages | Minimal invasiveness, easily repeatable |
| Challenge | Lower concentration, requires ultrasensitive assays |
| Platforms | Simoa, Ella, Lumipulse |
| Correlation with CSF | r = 0.70-0.80 |
| Reference range | ~100-200 pg/mL in healthy controls |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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