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Cell: Excitotoxicity-Vulnerable Neurons
cell
1,877 words
KG: excitotoxicity
2026-03-27
kind:cell-type
section:cell-types
state:published
Contents
Excitotoxicity-Vulnerable Neurons
🧫
Cell Type Info
Cell Type
Excitotoxicity-Vulnerable Neurons
Related Genes
glutamate receptors
,
NPY
,
HMGCR
,
glutamate
,
glutamate_receptors
,
STIM1
Linked Hypotheses
47 hypotheses
Knowledge Graph
Related Hypotheses (30)
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Multi-Modal Stress Response Harmonization
Score: 0.60
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Microbial Inflammasome Priming Prevention
Score: 0.58
PARP1 Inhibition Therapy
Score: 0.58
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
Purinergic Signaling Polarization Control
Score: 0.55
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Multiplexed Base Editing for Simultaneous Neuroprotective Ge
Score: 0.53
Ganglioside Rebalancing Therapy
Score: 0.50
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.49
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47
Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo
Score: 0.47
Arginine Methylation Enhancement Therapy
Score: 0.46
Cryptic Exon Silencing Restoration
Score: 0.46
HDAC3-Selective Inhibition for Clock Reset
Score: 0.46
Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.45
Lysosomal Membrane Repair Enhancement
Score: 0.45
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.45
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.44
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44
Show 25 more
Related Analyses (25)
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Mitochondrial transfer between neurons and glia
neurodegeneration · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · failed
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
Show 20 more
Related Experiments (4)
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
AMPK knockdown validation experiment
exploratory · proposed · Score: 0.88
iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85
See Also (3)
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: debate_co_mention
Knowledge Graph (12 edges)
excitotoxicity
associated_with
Amyotrophic lateral sclerosis
excitotoxicity
activates
STIM1
excitotoxicity
co_mentioned
neuroinflammation
excitotoxicity
co_mentioned
ferroptosis
excitotoxicity
associated_with
neuroinflammation
excitotoxicity
activates
SST
excitotoxicity
associated_with
MIRO1
excitotoxicity
co_mentioned
MIRO1
excitotoxicity
associated_with
TRKB
excitotoxicity
activates
HK2