Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about glutamate: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GLUTAMATE |
| Summary | Page for Fiber Photometry |
| KG Connections | 505 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
glutamate["glutamate"] -->|"released by"| neurons["neurons"]
style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
glutamate["glutamate"] -->|"active in"| hippocampus["hippocampus"]
style hippocampus fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
glutamate["glutamate"] -->|"released by"| astrocytes["astrocytes"]
style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
glutamate["glutamate"] -->|"active in"| cortex["cortex"]
style cortex fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
glutamate["glutamate"] -->|"released by"| neural_stem_cells["neural stem cells"]
style neural_stem_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
glutamate["glutamate"] -->|"released by"| macrophages["macrophages"]
style macrophages fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
glutamate["glutamate"] -->|"released by"| microglia["microglia"]
style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
NMDA_receptor["NMDA receptor"] -->|"binds"| glutamate["glutamate"]
style NMDA_receptor fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
AMPA_receptor["AMPA receptor"] -->|"binds"| glutamate["glutamate"]
style AMPA_receptor fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
spinal_muscular_atrophy["spinal muscular atrophy"] -->|"disrupts"| glutamate["glutamate"]
style spinal_muscular_atrophy fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
neurodegeneration["neurodegeneration"] -->|"disrupts"| glutamate["glutamate"]
style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
glutamate_receptor["glutamate receptor"] -->|"binds"| glutamate["glutamate"]
style glutamate_receptor fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
style glutamate fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| excitotoxicity | causes | process | 0.70 |
| motor neuron | causes | cell_type | 0.70 |
| neurodegeneration | activates | disease | 0.70 |
| motor neuron | activates | cell_type | 0.70 |
| hippocampus | loss_affects | entity | 0.60 |
| GABA | loss_affects | entity | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GFAP | loss_affects | entity | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||