| Gene Symbol | ent-gene-003014d4 |
| Chromosome | 1p33 |
| Function | ### Arousal and Wakefulness |
| Morphology | hypocretin-secreting neuron (source: Cell Ontology) |
| Orexin-A (hypocretin-1) | A 33-amino acid peptide with two intramolecular disulfide bonds |
| Orexin-B (hypocretin-2) | A 28-amino acid linear peptide |
| Extracellular N-terminus | Contains glycosylation sites important for ligand binding |
| Transmembrane domains | Seven hydrophobic helices that form the receptor core |
| Intracellular C-terminus | Couples to G proteins and contains phosphorylation sites for receptor regulation |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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