| Gene Symbol | ent-gene-7b80a607 |
| Subcellular Localization | in the brain: [@lipton2019] |
| Components | mTOR, Rictor, mLST8, mSin1, Protor-1/2 |
| Sensors | Growth factors (via PI3K signaling) |
| Inhibitors | Rapamycin, Torin1, PP242 |
| Functions | Actin cytoskeleton, cell survival, AKT phosphorylation |
| Hippocampus | High expression in CA1 pyramidal neurons, dentate gyrus granule cells |
| Cortex | Layer 2/3 pyramidal neurons show robust mTOR activity |
| Cerebellum | Purkinje cells have prominent mTOR signaling |
| Substantia nigra | Dopaminergic neurons express mTOR components |
| Basal ganglia | Medium spiny neurons show mTOR regulation |
| Dendrites | mTOR localizes to dendritic shafts and spines, enabling local protein synthesis |
| Soma | Perikaryal mTOR regulates global protein synthesis |
| Postsynaptic densities | mTORC1 associated with NMDA and AMPA receptor complexes |
| Axon initial segment | mTOR regulates axonal protein synthesis |
| Lysosomes | mTORC1 senses amino acid availability at lysosomal surface |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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