| Gene Symbol | ent-gene-98f9aec0 |
| Chromosome | 8p12 |
| Subcellular Localization | Within neurons, PSD-95 is concentrated in dendritic spines, particularly in the postsynaptic density (PSD) of excitatory |
| One SH3 domain | This domain recognizes proline-rich sequences and contributes to protein complex assembly. |
| One GK domain | The guanylate kinase-like domain provides additional protein interaction surfaces and mediates binding to Kaiserzeichen (MAGUK) family proteins. |
| Cortex | Layer 2/3 and layer 5 pyramidal neurons show robust PSD-95 expression. These neurons are involved in cortical processing and are affected early in AD. |
| Striatum | Medium spiny neurons (MSNs) express PSD-95 at both glutamatergic and dopaminergic synapses, where it regulates striatal plasticity relevant to PD. |
| Thalamus | Relay neurons in the ventral posteromedial (VPM) and ventral posterolateral (VPL) nuclei contain PSD-95, important for sensory transmission. |
| Kinases | CaMKII, PKA, and Src family kinases bind to PSD-95, positioning them to modulate receptor function. |
| Phosphatases | Calcineurin and PP1 interact with PSD-95, regulating dephosphorylation events. |
| Small GTPases | PSD-95 associates with Ras and Rap signaling complexes. |
| Receptor trafficking | LTP induces recruitment of additional NMDA and AMPA receptors to synapses, with PSD-95 facilitating this process. |
| Spine enlargement | Activity-dependent phosphorylation of PSD-95 promotes spine growth. |
| PSD reorganization | LTP triggers assembly of larger PSD complexes containing more PSD-95 molecules. |
| AMPA receptor internalization | PSD-95 interactions with the endocytic machinery promote removal of AMPA receptors. |
| Spin shrinkage | LTD is associated with spine shrinkage that requires cytoskeletal remodeling. |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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