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clinical_trial 3,309 words KG: ent-drug-4d620535
Contents

al002-trem2-agonist-alzheimers

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Wikipedia

Related Hypotheses (21)

Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
← Prevpg 2/2

Related Analyses (17)

Does SYK activation provide neuroprotection or exacerbate ne
neurodegeneration · archivedNeuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archivedNeuroinflammation and microglial priming in early AD
neurodegeneration · completedAstrocyte Reactivity Subtypes in Neurodegeneration
neurodegeneration · archivedImmune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · completed

Related Experiments (6)

Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (15)

TREM2 Protein — Triggering Receptor Expressed on Myeloi
protein · Pages share 8 hypothesesTREM2 Agonist Therapy for Neurodegeneration
therapeutic · Pages share 8 hypothesesTREM2 Signaling in Neurodegeneration
mechanism · Pages share 7 hypothesesTREM2 Microglial Signaling Pathway in Neurodegeneration
mechanism · Pages share 7 hypothesesTREM2-APOE Axis in Neurodegeneration
mechanism · Pages share 7 hypotheses

Knowledge Graph (9 edges)

41787076 demonstrated sustained target engagement and pharmacodynamic responses in ent-drug-4d620535
41787076 did not meet primary endpoint of change from baseline in ent-drug-4d620535
41787076 demonstrated sustained target engagement in ent-drug-4d620535
41787076 reduced ent-drug-4d620535
41787076 increased ent-drug-4d620535
41787076 demonstrates ent-drug-4d620535
41787076 reduces ent-drug-4d620535
41787076 increases ent-drug-4d620535
41787076 associated with ent-drug-4d620535

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