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therapeutic 1,441 words KG: ent-gene-28e2cb01 2026-03-23
kind:therapeuticsection:therapeuticsstate:publishedtarget:trem2
Contents

TREM2 Agonist Therapy for Neurodegeneration

🔬 Protein Info
Gene Symbolent-gene-28e2cb01
TrialPhase
INVOKE-2Phase 2
Phase 1Phase 1
AgentCompany
AL002Alector/AbbVie
AL003Alector
HL-85H3 Biomedicine/Eisai
H3B-10252H3 Biomedicine
KG Connections5 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegen
Score: 0.64TREM2-Mediated Astrocyte-Microglia Cross-Talk in Neurodegene
Score: 0.61TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener
Score: 0.61TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming
Score: 0.59TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging
Score: 0.59

Related Analyses (30)

Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · completedNeuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archivedNeuroinflammation and microglial priming in early AD
neurodegeneration · completedTREM2 Therapeutic Strategy Post-INVOKE-2
neurodegeneration · archivedMechanistic validation of SEA-AD differential expression hyp
neurodegeneration · failed

Related Experiments (30)

Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.46TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.46TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.46TREM2 KO amyloid pathology study
validation · completed · Score: 0.75TREM2 KO amyloid pathology study
validation · completed · Score: 0.75

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 139 hypothesesWNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 139 hypothesesvip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 139 hypothesesVEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 139 hypothesesVagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses

Knowledge Graph (5 edges)

ent-gene-28e2cb01 expressed_in microglia
ent-gene-28e2cb01 data_in ad_genetic_risk_loci:TREM2
ent-gene-28e2cb01 data_in benchmark_ot_ad_answer_key:TREM2
ad_genetic_risk_loci:TREM2 data_in ent-gene-28e2cb01
benchmark_ot_ad_answer_key:TREM2 data_in ent-gene-28e2cb01
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