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Home / Wiki / Clinical: ARC-IM Adaptive Neurostimulation for PD

clinical 789 words KG: ARC 2026-03-22

kind:clinical-trial section:clinical-trials state:published

Contents

ARC-IM Adaptive Neurostimulation for PD

Knowledge Graph

Related Hypotheses (8)

Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95
Score: 0.69 Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68 Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67 Multiplexed Base Editing for Simultaneous Neuroprotective Ge
Score: 0.53 Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.48

Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.47 FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.39 Synaptic Vesicle Tau Capture Inhibition
Score: 0.34

Related Analyses (15)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived TDP-43 phase separation therapeutics for ALS-FTD
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neurodegeneration · completed

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived Mitochondrial transfer between neurons and glia
neurodegeneration · archived Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived Circuit-level neural dynamics in neurodegeneration
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neurodegeneration · archived Extracellular vesicle biomarkers for early AD detection
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neurodegeneration · archived

Related Experiments (8)

Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40 tACS Connectivity Trial in Early Alzheimer's
clinical · proposed · Score: 0.40 Microbiome-Gut Barrier Signatures in ALS — Experiment Design
clinical · proposed · Score: 0.40 cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40 Levodopa-Induced Dyskinesias Mechanism — Experiment Design
validation · proposed · Score: 0.40

Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40 Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40 Sirtuin Pathway Dysfunction Validation in Parkinson's Diseas
clinical · proposed · Score: 0.40

See Also (7)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates Alzheimer Indonesia
institution · KG edge: inhibits Apoptosis in Neurodegeneration
entity · KG edge: activates AMPK (AMP-Activated Protein Kinase)
entity · KG edge: therapeutic_target

ATP P2X3 Receptor Neurons
cell · KG edge: associated_with AgRP (Agouti-Related Protein) Neurons
cell · KG edge: produces

Knowledge Graph (12 edges)

ARC produces NPY

ARC produces AGRP

ARC produces POMC

ARC regulates POMC

ARC regulates NPY

ARC regulates CRH

ARC interacts_with NTS

ARC therapeutic_target FOXO3

ARC expressed_in Hypothalamus

ARC expressed_in Brainstem

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