| Gene Symbol | POMC |
| Full Name | Proopiomelanocortin |
| Chromosome | 2p23.3 |
| Function | encodes a precursor protein that is cleaved to produce multiple biologically active peptides, including α-melanocyte stimulating hormone (α-MSH), β-endorphin, and adrenocorticotropic hormone (ACTH). |
| Primary Expression | the pituitary gland, hypothalamus, and skin melanocytes [@pomc] |
| Amino Acids | 267 aa |
| Exons | 3 exons encoding the 267-amino acid POMC precursor |
| Pathways | Amyloid, Cholesterol, Cholesterol Metabolism, Er Stress, Immune Response |
| GeneCards | POMC |
| Human Protein Atlas | POMC |
| Chromosomal location | 2p23.3 |
| Gene length | Approximately 8.5 kb |
| Promoter | Contains response elements for glucocorticoids, leptin, and inflammatory cytokines |
| Leptin | Positively regulates POMC transcription in hypothalamic neurons |
| Glucocorticoids | Suppress POMC expression in pituitary corticotrophs |
| Associated Diseases | Alopecia Areata, ALS, Alzheimer, Cancer, Hypertension, Ptsd |
| Interactions | AIF1, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID, ANXIETY |
| KG Connections | 180 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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