clinical 936 words KG: ent-gene-8820fc89 2026-03-22
kind:clinical-trialsection:clinical-trialsstate:published
Contents

IL-2 Immunotherapy for AD Neuroinflammation (NCT06384378)

🔬 Protein Info
Gene SymbolIL
Full Name2 Immunotherapy for Alzheimer's Disease Neuroinflammation (NCT06384378)
FunctionInterleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation.
GeneCardsIL
Human Protein AtlasIL
PhasePhase 2
StatusRecruiting
SponsorThe Methodist Hospital Research Institute
InterventionLow-dose IL-2 (interleukin-2) immunotherapy
IndicationAlzheimer's Disease
Study DesignRandomized, quadruple-blind, parallel assignment
Enrollment40 participants
LocationHouston Methodist Research Institute, Houston, Texas
Associated DiseasesCRC
KG Connections1 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.49
TREM2-mediated microglial tau clearance enhancement
Score: 0.49

Related Analyses (3)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · completed

Related Experiments (10)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice
falsification · proposed · Score: 0.40
s:** - GPR32 knockout in microglia should worsen neuroinflam
falsification · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-8820fc89 data_in benchmark_ot_ad_answer_key:IL2
benchmark_ot_ad_answer_key:IL2 data_in ent-gene-8820fc89