| Pure PART | Significant NFTs with no amyloid plaques (Thal phase 0) |
| PART with low amyloid | Moderate NFTs with sparse amyloid plaques (Thal phase 1-2) |
| Alzheimer's disease | Both significant NFTs and amyloid plaques (Thal phase 3-5) |
| PART | Similar to AD, shows a balanced 3R:4R ratio (~1:1), reflecting the inclusion of all six isoforms in NFT formation |
| CBD/PSP | Dominance of 4R tau (4R:3R ratio ~2-3:1) |
| CBD | 4R tau predominance in astrocytic plaques and coiled bodies |
| 3R/4R balance | The balanced ratio in PART distinguishes it from pure 4R tauopathies like CBD and PSP |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
No AI portrait yet
No comments yet. Be the first to comment!