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Home / Wiki / Disease: Autism Spectrum Disorder

disease 1,185 words KG: ent-dise-176b17e8 2026-03-24

kind:disease section:diseases state:published

Contents

Autism Spectrum Disorder

Knowledge Graph

Related Hypotheses (20)

Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59 Complement C1q Mimetic Decoy Therapy
Score: 0.48 Microbiota-Microglia Axis Modulation
Score: 0.48 Synaptic Pruning Precision Therapy
Score: 0.47 Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming
Score: 0.61

Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S
Score: 0.60 Microbial Inflammasome Priming Prevention
Score: 0.58 TREM2-Dependent Microglial Senescence Transition
Score: 0.69 APOE-Dependent Autophagy Restoration
Score: 0.61 Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52 Lysosomal Calcium Channel Modulation Therapy
Score: 0.49 Lysosomal Enzyme Trafficking Correction
Score: 0.49 TREM2-mediated microglial tau clearance enhancement
Score: 0.49 APOE-TREM2 Interaction Modulation
Score: 0.48 Lysosomal Membrane Repair Enhancement
Score: 0.45 TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.43 Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43 Lysosomal Positioning Dynamics Modulation
Score: 0.43 Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.43 TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41

Related Analyses (7)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived Synaptic pruning by microglia in early AD
neurodegeneration · archived Circuit-level neural dynamics in neurodegeneration
neuroscience · archived Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Microglial subtypes in neurodegeneration — friend vs foe
neuroscience · failed Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

Related Experiments (9)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40 Cytochrome Therapeutics
clinical · proposed · Score: 0.40 iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90 RBG treatment in ApoE-/- atherosclerosis mouse model
validation · proposed · Score: 0.90 Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90

P2RY12-MTOR pathway interaction in VSMCs
exploratory · proposed · Score: 0.85 iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85 Reelin pathway defects in human type 2 lissencephaly
exploratory · proposed · Score: 0.70 NLRP3 Inflammasome Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

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