| United States | Approximately 1 in 36 children (2023 CDC estimate) |
| Global | Estimated 1 in 100 children worldwide (WHO) |
| Gender ratio | Males are diagnosed 4-5x more frequently than females |
| Age of diagnosis | Median age of diagnosis is 4-5 years, though earlier identification is possible |
| Genetic factors | Heritability estimated at 60-90% |
| Advanced parental age | Both maternal and paternal |
| Premature birth | Especially before 35 weeks gestation |
| Prenatal exposures | Certain medications, toxins |
| Sibling risk | Higher risk in families with one affected child |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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