disease 2,884 words KG: ent-dise-973e0e39 2026-03-29
kind:diseasesection:diseasesstate:publishedevidence:strong
Contents

Dementia with Lewy Bodies (DLB)

Disease Info
Prevalence0.3-1.9% of the population over age 65, rising to 3-5% in those over 85[@zaccai2023]
IncidenceApproximately 0.5-1.0 new cases per 1000 person-years in those over 65
SexSlightly more common in males
Age of onsetTypically 65-85 years, with mean age around 75 years
SurvivalMedian survival from diagnosis is 4-6 years, shorter than AD but comparable to PDD
DatabasesOMIMOrphanetClinicalTrialsPubMed

Knowledge Graph

Related Hypotheses (9)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Smartphone-Detected Motor Variability Correction
Score: 0.56
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (6)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (10)

Alpha-Synuclein Staging and Spreading in DLB — Spatial Propa
validation · proposed · Score: 0.40
Cholinergic System Dysfunction in DLB — Mechanisms and Thera
clinical · proposed · Score: 0.40
DLB Cognitive Fluctuation Mechanism Experiment
clinical · proposed · Score: 0.40
Genetic Risk Modifiers in DLB Phenotype
clinical · proposed · Score: 0.40
Tau Co-Pathology in DLB Clinical Heterogeneity
clinical · proposed · Score: 0.40