disease 927 words KG: Executive Dysfunction in Corticobasal Syndrome 2026-03-28
kind:diseasesection:diseasesstate:published
Contents

Executive Dysfunction in Corticobasal Syndrome

Disease Info
Caudate nucleusExecutive selection and sequence planning
Globus pallidusMotor programming and inhibition
ThalamusExecutive attention and working memory gating
Superior longitudinal fasciculusFrontoparietal executive networks
Corpus callosumInterhemispheric executive integration
Frontostriatal loopsCortico-subcortical executive circuits
Increased switch costMarked slowing when transitioning between tasks
PerseverationContinuation of previous response set
Reduced flexibilityInability to adapt to changing demands
Set-loss errorsFailure to maintain task rules
Reduced planning abilityInability to devise multi-step strategies
KG Connections1 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

Knowledge Graph

Related Hypotheses (26)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.69
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.68
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.66
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.65
Retinal Vascular Microcirculation Rescue
Score: 0.62

Related Analyses (20)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · completed

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

Knowledge Graph (1 edges)

Executive Dysfunction in Corticobasal Syndrome type_of neurodegenerative_diseases