disease 3,094 words KG: ent-dise-615bf469 2026-03-24
kind:diseasesection:diseasesstate:published
Contents

Genetics of Progressive Supranuclear Palsy

Disease Info
H1 haplotype3-6x increased risk in homozygous individuals
STX6 genePrevious GWAS identified syntaxin-6 as a risk modifier
EIF2AK3Involved in unfolded protein response
MOBPMyelin-associated oligodendrocyte basic protein
SLCO1A2Solute carrier organic anion transporter
DatabasesOMIMOrphanetClinicalTrialsPubMed

Knowledge Graph

Related Hypotheses (25)

Glymphatic-Mediated Tau Clearance Dysfunction
Score: 0.55
Dual-Circuit Tau Vulnerability Cascade
Score: 0.50
Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio
Score: 0.49
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.56
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56

Related Analyses (13)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Do tau strains or regional cellular environments primarily d
neurodegeneration · failed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (25)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40