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disease 3,094 words KG: ent-dise-615bf469
Contents

Genetics of Progressive Supranuclear Palsy

Disease Info
H1 haplotype3-6x increased risk in homozygous individuals
STX6 genePrevious GWAS identified syntaxin-6 as a risk modifier
EIF2AK3Involved in unfolded protein response
MOBPMyelin-associated oligodendrocyte basic protein
SLCO1A2Solute carrier organic anion transporter
DatabasesOMIMOrphanetClinicalTrialsPubMed

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OMIMMeSHWikipedia

Related Hypotheses (22)

Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76Smartphone-Detected Motor Variability Correction
Score: 0.74Aquaporin-4 Polarization Rescue
Score: 0.73Phase-Separated Organelle Targeting
Score: 0.73Noradrenergic-Tau Propagation Blockade
Score: 0.71Microglial Purinergic Reprogramming
Score: 0.70Glial Glycocalyx Remodeling Therapy
Score: 0.65Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64Sphingolipid Metabolism Reprogramming
Score: 0.62Synaptic Vesicle Tau Capture Inhibition
Score: 0.58Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75APOE-TREM2 Interaction Modulation
Score: 0.74Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69TREM2-Dependent Microglial Senescence Transition
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.62
pg 1/2Next →

Related Analyses (12)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedMetabolic reprogramming in neurodegenerative disease
neurodegeneration · completedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (25)

Viral and Post-Infectious Mechanisms in ALS — Experiment Des
clinical · proposed · Score: 0.40PSP and CBS Biomarker Validation Study
clinical · proposed · Score: 0.40Sleep and Respiratory Network Interaction in ALS — Experimen
clinical · proposed · Score: 0.40TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40

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