gene 2,015 words KG: ADAM22 2026-03-27
kind:genesection:genesstate:published
Contents

ADAM22 — ADAM Metallopeptidase Domain 22

🧬 Gene Info
Gene SymbolADAM22
Full NameADAM Metallopeptidase Domain 22
Chromosome7q21.2
Functionis a member of the ADAM family of transmembrane proteins that plays a critical role in synaptic function and neurological disease.
Amino Acids834 aa
Exons24
UniProt ID[Q9P121](https://www.uniprot.org/uniprot/Q9P121)
Ensembl IDENSG00000010704
OMIM605283
GeneCardsADAM22
Human Protein AtlasADAM22
Cerebral CortexParticularly layer V pyramidal neurons
HippocampusCA1 and CA3 regions, dentate gyrus granule cells
CerebellumPurkinje cells and deep cerebellar nuclei
BrainstemSensory and motor nuclei
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.46
Glycine-Rich Domain Competitive Inhibition
Score: 0.43
Low Complexity Domain Cross-Linking Inhibition
Score: 0.42

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (2 edges)

ADAM22 data_in benchmark_ot_ad_answer_key:ADAM22
benchmark_ot_ad_answer_key:ADAM22 data_in ADAM22