gene 603 words KG: C12ORF65 2026-03-24
kind:genesection:genesstate:published
Contents

C12orf65 - Mitochondrial Release Factor

🧬 Gene Info
Gene SymbolC12ORF65
Full NameChromosome 12 Open Reading Frame 65
AliasesPage for C12orf65
Chromosome12
FunctionC12orf65 (also known as mitochondrial release factor) is a mitochondrial matrix protein that functions as a peptide release factor in mitochondrial translation termination.
UniProt ID[Q5R390](https://www.uniprot.org/uniprot/Q5R390)
Ensembl IDENSG00000178732
GeneCardsC12ORF65
Human Protein AtlasC12ORF65
BrainCerebral cortex, basal ganglia, brainstem
RetinaHigh expression in retinal ganglion cells
Skeletal muscleHigh metabolic demand
HeartCardiac muscle
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Mitochondrial Transfer Pathway Enhancement
Score: 0.44

Related Analyses (10)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in