gene 603 words KG: C12ORF65
Contents

C12orf65 - Mitochondrial Release Factor

🧬 Gene Info
Gene SymbolC12ORF65
Full NameChromosome 12 Open Reading Frame 65
AliasesPage for C12orf65
Chromosome12
FunctionC12orf65 (also known as mitochondrial release factor) is a mitochondrial matrix protein that functions as a peptide release factor in mitochondrial translation termination.
UniProt ID[Q5R390](https://www.uniprot.org/uniprot/Q5R390)
Ensembl IDENSG00000178732
GeneCardsC12ORF65
Human Protein AtlasC12ORF65
BrainCerebral cortex, basal ganglia, brainstem
RetinaHigh expression in retinal ganglion cells
Skeletal muscleHigh metabolic demand
HeartCardiac muscle
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

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NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57

Related Analyses (10)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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