| Gene Symbol | CDC25C |
| Full Name | Cell Division Cycle 25C |
| Chromosome | 5q31.2 |
| Protein Type | Protein |
| Function | is a dual-specificity phosphatase that plays a critical role in cell cycle regulation by removing inhibitory phosphates from cyclin-dependent kinases (CDKs). |
| Subcellular Localization | The localization of CDC25C is tightly regulated throughout the cell cycle[@cdc25c_localization_2016]: |
| Molecular Weight | 53 kDa |
| Amino Acids | 473 aa |
| Exons | 14 |
| UniProt ID | Search UniProt |
| GeneCards | CDC25C |
| Human Protein Atlas | CDC25C |
| Activation of CDK1 | CDC25C removes inhibitory phosphates from CDK1 at Tyr15 (by WEE1 kinase) and Thr14 (by MYT1 kinase) |
| Positive feedback loop | CDK1/cyclin B phosphorylates and activates CDC25C, creating a positive feedback loop that ensures irreversible mitotic entry |
| Checkpoint recovery | Following DNA repair, CDC25C activity is restored to allow cell cycle progression |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
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