gene 878 words KG: DAXX
Contents

DAXX Gene

🧬 Gene Info
Gene SymbolDAXX
Full NameDeath-Domain Associated Protein
Chromosome6p21.3.
Functionis a multifunctional protein encoded by the DAXX gene located on chromosome 6p21.
Amino Acids740 aa
UniProt IDQ9UER7
NCBI Gene ID1616
Ensembl IDENSG00000204264
OMIM603186
GeneCardsDAXX
Human Protein AtlasDAXX
Transcriptional regulatorModulates gene expression through histone modification
Associated Diseasesneurodegeneration
KG Connections21 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (11)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (6)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

See Also (7)

Neurodegeneration
disease · KG edge: implicated_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: regulates
BDNF Gene
gene · KG edge: regulates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: regulates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates

Knowledge Graph (12 edges)

DAXX regulates BDNF
DAXX regulates APP
DAXX regulates APOE
APP regulates DAXX
BDNF regulates DAXX
APOE regulates DAXX
DAXX treats ALZHEIMER
DAXX regulates AMYLOID
DAXX treats CANCER
DAXX treats ALZHEIMER'S DISEASE

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