| Gene Symbol | DCLRE1A |
| Full Name | DNA Cross-Link Repair 1A |
| Chromosome | 10q26.3 |
| Function | encodes a member of the metallo-beta-lactamase superfamily of nucleases involved in DNA repair. |
| Primary Expression | Ubiquitous, high in brain |
| UniProt ID | [Q9H9Y6](https://www.uniprot.org/uniprotkb/Q9H9Y6/entry) |
| GeneCards | DCLRE1A |
| Human Protein Atlas | DCLRE1A |
| ICL unhooking | Cleaves the DNA on one side of the crosslink, releasing one strand for translesion synthesis |
| Strand resection | Generates 3' overhangs that facilitate homologous recombination |
| Drafting | Removes blocking nucleotides during DNA repair synthesis |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
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