gene 1,574 words KG: GEMIN4
Contents

GEMIN4 Gene

🧬 Gene Info
Gene SymbolGEMIN4
Chromosome17p13.2
Functionis a critical component of the SMN (Survival Motor Neuron) complex, which is essential for the biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs).
Primary Expressionhuman tissues with highest expression in the brain, spinal cord, and testis [1](https://pubmed
Molecular Weight116 kDa
Amino Acids058 aa
Exons15
Ensembl IDENSG00000176490
GeneCardsGEMIN4
Human Protein AtlasGEMIN4
Associated DiseasesALS through multiple mechanisms [4](https://pubmed
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (10)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Cryptic Exon Silencing Restoration
Score: 0.53
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Axonal RNA Transport Reconstitution
Score: 0.70
RNA Granule Nucleation Site Modulation
Score: 0.66
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (2 edges)

GEMIN4 data_in benchmark_ot_ad_answer_key:GEMIN4
benchmark_ot_ad_answer_key:GEMIN4 data_in GEMIN4

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