gene 3,405 words KG: IL28B
Contents

IL28B (Interleukin 28B)

🧬 Gene Info
Gene SymbolIL28B
Full NameInterleukin 28B
Chromosome19q13.2
Protein FamilyType III Interferons (IFN-λ)
Primary Expressionvarious brain cell types including neurons, astrocytes, and microglia, where they contribute to neuroinflammation, antiviral defense, and potentially
Molecular Weight22 kDa
Amino Acids200 aa
Exons5
UniProt IDQ8IZI9
NCBI Gene ID282617
Ensembl IDENSG00000184226
OMIM607402
GeneCardsIL28B
Human Protein AtlasIL28B
Associated DiseasesAlzheimer's disease, Parkinson's disease
DatabasesGeneCardsHPASTRING

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NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE-TREM2 Interaction Modulation
Score: 0.74
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58

Related Analyses (3)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (6)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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