gene 1,103 words KG: KCA1A 2026-03-27
kind:genesection:genesstate:publishedtopic:ion-channelstopic:alzheimerstopic:parkinsonstopic:excitabilitytopic:synaptic-plasticity
Contents

KCA1A Gene

🧬 Gene Info
Gene SymbolKCA1A
Full NamePotassium Calcium-Activated Channel Subfamily M Member 1
Chromosome10p12
FunctionKCNMB1-4 (β1-4): Beta subunits that modify channel kinetics and pharmacology
Molecular Weight125 kDa
Amino Acids1000 aa
Exons26
UniProt ID[Q12791](https://www.uniprot.org/uniprot/Q12791)
Ensembl IDENSG00000156170
GeneCardsKCA1A
Human Protein AtlasKCA1A
KCNMB1-4 (β1-4)Beta subunits that modify channel kinetics and pharmacology
KCNIP1-4 (γ1-4)Gamma subunits that sense intracellular signaling molecules
Conductance~200-250 pS in physiological K+ gradients (among the largest K+ conductances)
SelectivityHighly selective for K+ over Na+ and Ca2+
Associated DiseasesAlzheimer's disease, Parkinson's disease
DatabasesGeneCardsNCBI GeneHPASTRING

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