| Gene Symbol | LIN7C |
| Function | The LIN7C gene encodes LIN-7 Homolog C, a member of the LIN7 family of proteins (also known as VELI or MAGUK proteins). |
| Primary Expression | both neuronal and non-neuronal tissues |
| Subcellular Localization | synaptic compartments, where they function as crucial organizers of postsynaptic density (PSD) architecture[@bhattachary |
| Amino Acids | 211 aa |
| Ensembl ID | ENSG00000114854 |
| GeneCards | LIN7C |
| Human Protein Atlas | LIN7C |
| C-terminal region | This region contains targeting signals that direct LIN7C to specific subcellular compartments, particularly dendritic spines and postsynaptic densities. |
| AMPA receptor subunits | LIN7C binds to the C-terminal tails of GluA1, GluA2, and GluA3 subunits, facilitating proper synaptic localization and trafficking of AMPA receptors |
| NMDA receptor subunits | Interactions with NR2A and NR2B subunits position LIN7C in postsynaptic densities |
| Metabotropic glutamate receptors | Links to Group I mGluRs (mGluR1, mGluR5) |
| PSD-95 | Forms complexes that anchor receptors to the postsynaptic density |
| SAP97 | Participates in dendritic targeting of proteins |
| CASK | LIN7 interacts with this presynaptic partner for trans-synaptic signaling |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |