gene 2,174 words KG: MARS2 2026-03-26
kind:genesection:genesstate:published
Contents

MARS2 — Mitochondrial Arginyl-tRNA Synthetase 2

🧬 Gene Info
Gene SymbolMARS2
Full NameMitochondrial Arginyl-tRNA Synthetase 2
Chromosome2q33.1
Protein TypeSynthetase
Functionencodes a mitochondrial aminoacyl-tRNA synthetase (mtARS) that specifically charges arginine to its cognate mitochondrial tRNA.
Primary Expressiontissues with high mitochondrial energy demands:
Molecular Weight65 kDa
Amino Acids577 aa
UniProt ID[Q9N3W4](https://www.uniprot.org/uniprot/Q9N3W4)
Ensembl IDENSG00000135953
GeneCardsMARS2
Human Protein AtlasMARS2
LengthApproximately 577 amino acids
Molecular weight~65 kDa
DomainsContains the catalytic domain typical of class I aminoacyl-tRNA synthetases
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (14)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (11)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in