| Gene Symbol | NTN2 |
| Full Name | Netrin-2 |
| Chromosome | 19p13.3 |
| Protein Family | Netrin |
| Function | is a secreted laminin-related protein that plays crucial roles in axon guidance during neural development. |
| Primary Expression | spinal cord, brainstem, and cerebellum |
| Pathways | Axon Guidance |
| UniProt ID | [Q8WWS8](https://www.uniprot.org/uniprot/Q8WWS8) |
| GeneCards | NTN2 |
| Human Protein Atlas | NTN2 |
| N-terminal domain | Contains the receptor-binding sites for DCC and UNC5 family receptors |
| Laminin VI domain | Shared with laminin proteins, mediates heparin binding |
| Laminin V domain | C-terminal domain important for secretion and extracellular matrix interaction |
| C-terminal domain | Contains a heparin-binding site that regulates gradient formation |
| Neogenin | A DCC homolog that also binds netrins, involved in tissue boundary formation |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!