| Gene Symbol | PON2 |
| Full Name | Paraoxonase 2 |
| Chromosome | 7q21.3 |
| Primary Expression | the liver and secreted into the plasma, PON2 exhibits a broader tissue distribution with particularly high expression in the brain, lung, and heart |
| Subcellular Localization | positions PON2 at critical intersections of cellular metabolism, where it exerts potent antioxidant, anti-apoptotic, and |
| Amino Acids | 354 aa |
| UniProt ID | [Q15165](https://www.uniprot.org/uniprot/Q15165) |
| Ensembl ID | ENSG00000105855 |
| GeneCards | PON2 |
| Human Protein Atlas | PON2 |
| N-terminal signal sequence | Unlike secreted PON1 and PON3, PON2 lacks a classical secretory signal peptide, explaining its intracellular retention. |
| N-terminal hydrophobic domain | A hydrophobic N-terminal region anchors PON2 to intracellular membranes, particularly the endoplasmic reticulum and mitochondrial outer membrane. |
| N-glycosylation sites | PON2 contains multiple N-linked glycosylation sites that are important for proper folding and stability. |
| Lactonase active site | The canonical paraoxonase active site comprises a lactonase domain that hydrolyzes a broad range of substrates. |
| Conserved serine hydrolase motif | A serine-lysine-histidine catalytic triad typical of the paraoxonase family. |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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