gene 2,043 words KG: RAB17 2026-03-27
kind:genesection:genesstate:publishedtopic:parkinsonstopic:alzheimerspathway:vesicle-trafficking
Contents

RAB17

🧬 Gene Info
Gene SymbolRAB17
Full NameMember RAS Oncogene Family 17
Chromosome2q37.2
Functionencodes a member of the Rab GTPase family, which constitutes the largest family of small GTP-binding proteins involved in regulating intracellular membrane trafficking.
Subcellular Localizationand function in membrane trafficking pathways
Amino Acids213 aa
UniProt ID[Q9H0T7](https://www.uniprot.org/uniprot/Q9H0T7)
Ensembl IDENSG00000124839
GeneCardsRAB17
Human Protein AtlasRAB17
GTP-bound stateActive, can interact with effector proteins
GDP-bound stateInactive, cytosolic
GDI (GDP Dissociation Inhibitor)Extracts GDP-bound RAB from membranes
GDF (GDI Displacement Factor)Releases RAB from GDI
GAP (GTPase Activating Protein)Inactivates RAB by stimulating GTP hydrolysis
Associated DiseasesParkinson's disease, Alzheimer's disease
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph