| Gene Symbol | RAB40B |
| Full Name | Member RAS Oncogene Family |
| Function | is a member of the Rab GTPase family characterized by the presence of a SOCS (Suppressor of Cytokine Signaling) box domain. |
| Primary Expression | neuronal tissues where it plays critical roles in endosomal trafficking, protein degradation pathways, and synaptic function |
| Subcellular Localization | and regulation of RAB40B is mediated through these GTPase regulatory proteins |
| Ensembl ID | ENSG00000120251 |
| GeneCards | RAB40B |
| Human Protein Atlas | RAB40B |
| Active (GTP-bound) state | When bound to GTP, RAB40B can interact with downstream effectors and participate in vesicle targeting |
| Inactive (GDP-bound) state | GDP-bound RAB40B is sequestered by GDP Dissociation Inhibitors (GDIs), which prevent inappropriate effector interactions |
| GDFs (GDP Dissociation Factors) | These proteins catalyze GDP release, allowing GTP binding |
| Rabin8/RABIN8 | A GEF that may activate RAB40B |
| RABP1 (Rabenosyn-5) | An effector involved in endosomal trafficking |
| ESCRT complex components | Proteins involved in multivesicular body formation |
| E3 ubiquitin ligases | Via the SOCS box domain |
| Associated Diseases | Parkinson's disease, Alzheimer's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |