| Gene Symbol | RBM45 |
| Chromosome | 2q32.1 |
| Function | is a neuronally-expressed RNA-binding protein that has emerged as a significant player in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). |
| Primary Expression | the central nervous system, with particularly high expression in motor neurons, cortical neurons, and hippocampal pyramidal cells |
| Molecular Weight | 46 kDa |
| Amino Acids | 405 aa |
| GeneCards | RBM45 |
| Human Protein Atlas | RBM45 |
| Condition | RBM45 Association |
| Alzheimer's Disease | Detected in tau inclusions, alters tau splicing |
| Parkinson's Disease | Stress granule accumulation in dopaminergic neurons |
| Huntington's Disease | Transcriptional dysregulation |
| Multiple Sclerosis | Altered expression in inflammatory demyelination |
| Approach | Mechanism |
| ASO Therapy | Modulate RBM45 splicing |
| Associated Diseases | neurodegeneration |
| Interactions | ASCT2 |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |