gene 1,768 words KG: SLC7A2 2026-03-26
kind:genesection:genesstate:published
Contents

SLC7A2 — Solute Carrier Family 7 Member 2 ( cationic amino acid transporter 2)

🧬 Gene Info
Gene SymbolSLC7A2
Full NameSolute Carrier Family 7 Member 2
Aliases cationic amino acid transporter 2
Chromosome8p22
Functionis a membrane protein that mediates the transport of cationic amino acids across cell membranes[@closs1996].
Primary Expressionneurons, astrocytes, microglia, and endothelial cells of the blood-brain barrier[@bertz2014] - Kidney: High expression in renal tubular cells[@sil
Molecular Weight70 kDa
Amino Acids630 aa
PathwaysInteraction
GeneCardsSLC7A2
Human Protein AtlasSLC7A2
PathwayInteraction
mTORRegulation by mTORC1
NF-κBCytokine-induced expression
MAPKSignaling downstream of NO
Associated Diseasesneurodegeneration
InteractionsMTORC1
KG Connections5 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (2)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (3)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (3)

Packard Center for ALS Research
institution · KG edge: inhibits
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: activates
Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (5 edges)

SLC7A2 activates MTORC1
SLC7A2 activates Diabetes
SLC7A2 inhibits Als
SLC7A2 activates Mtor
SLC7A2 activates Cell Cycle