pathway

Mtor

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Mtor: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9715Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Mtor is a biological pathway involved in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 2070 entities in the SciDEX knowledge graph.

View on Wiki →

🔀 Pathway Info

Name	mTOR
Key Genes/Proteins	MTOR, LC3, MYC, PTEN, PINK1, ULK1
Linked Hypotheses	4 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Mtor["Mtor"] -->|"interacts"| Lysosomal_Degradation["Lysosomal Degradation"]
    Mtor["Mtor"] -->|"interacts"| Autophagy["Autophagy"]
    Mtor["Mtor"] -->|"interacts"| Apoptosis["Apoptosis"]
    Mtor["Mtor"] -->|"interacts"| Mitophagy["Mitophagy"]
    Mtor["Mtor"] -->|"interacts"| Wnt["Wnt"]
    Mtor["Mtor"] -->|"interacts"| Ferroptosis["Ferroptosis"]
    ACTB["ACTB"] -->|"regulates"| Mtor["Mtor"]
    PPARA["PPARA"] -->|"regulates"| Mtor["Mtor"]
    CAT["CAT"] -->|"regulates"| Mtor["Mtor"]
    SQSTM1["SQSTM1"] -->|"regulates"| Mtor["Mtor"]
    style Mtor fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (4253)

Target	Relation	Type	Str
Alzheimer's Disease	associated_with	disease	0.85
Neuroinflammation	interacts_with	process	0.80
Pharmaco-resistant Seizures	associated_with	phenotype	0.75
Lysosomal Degradation	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Mitophagy	interacts_with	pathway	0.55
Wnt	interacts_with	pathway	0.55
Ferroptosis	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
Phagocytosis	interacts_with	pathway	0.55
Insulin Signaling	interacts_with	pathway	0.55
Glycolysis	interacts_with	pathway	0.55
Oxidative Phosphorylation	interacts_with	pathway	0.55
Synaptic Plasticity	interacts_with	pathway	0.55
Endocytosis	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
Dna Methylation	interacts_with	pathway	0.55
Tgf-Β	interacts_with	pathway	0.55
Mapk	interacts_with	pathway	0.55
Epigenetic	interacts_with	pathway	0.55
Proteasome	interacts_with	pathway	0.55
Jak-Stat	interacts_with	pathway	0.55
Immune Response	interacts_with	pathway	0.55
neurodegeneration	implicated_in	disease	0.50
Stem Cell	inhibits	cell_type	0.50
Neural Progenitor	associated_with	cell_type	0.50
Stem Cell	associated_with	cell_type	0.50
Neuron	activates	cell_type	0.50
Stem Cell	activates	cell_type	0.50
Epithelial	regulates	cell_type	0.50
Hepatocyte	activates	cell_type	0.50
Stem Cell	interacts_with	cell_type	0.50
Dendritic Cell	interacts_with	cell_type	0.50
Epithelial	interacts_with	cell_type	0.50
Neuron	encodes	cell_type	0.50
Interneuron	encodes	cell_type	0.50
Epithelial	associated_with	cell_type	0.50
Fibroblast	inhibits	cell_type	0.50
Neuron	associated_with	cell_type	0.50
Microglia	regulates	cell_type	0.50
Neuron	regulates	cell_type	0.50
Macrophage	regulates	cell_type	0.50
Microglia	associated_with	cell_type	0.50
Macrophage	associated_with	cell_type	0.50
Macrophage	expressed_in	cell_type	0.50
T Cell	associated_with	cell_type	0.50
Chondrocyte	activates	cell_type	0.50
Epithelial	causes	cell_type	0.50
Endothelial	associated_with	cell_type	0.50

Incoming (5462)

Source	Relation	Type	Str
MTOR	regulates	gene	1.00
LC3	inhibits	gene	1.00
MTOR	inhibits	gene	1.00
MTOR	associated_with	gene	1.00
MYC	activates	gene	1.00
MTOR	activates	gene	1.00
PTEN	activates	gene	1.00
LC3	associated_with	gene	1.00
PINK1	activates	gene	1.00
LC3	activates	gene	1.00
MTOR	therapeutic_target	gene	1.00
ULK1	activates	gene	1.00
SIRT1	activates	gene	1.00
BAX	activates	gene	1.00
MTOR	expressed_in	gene	1.00
SQSTM1	activates	gene	1.00
PI3K	inhibits	gene	1.00
AKT	inhibits	gene	1.00
GENES	inhibits	gene	1.00
Als	inhibits	disease	1.00
Cancer	interacts_with	disease	1.00
Als	interacts_with	disease	1.00
GENES	activates	gene	1.00
Neurodegeneration	activates	disease	1.00
Als	associated_with	disease	1.00
PI3K	activates	gene	1.00
AKT	activates	gene	1.00
Cancer	activates	disease	1.00
Als	activates	disease	1.00
Tumor	activates	disease	1.00
AMPK	activates	gene	1.00
Tumor	associated_with	disease	1.00
PI3K	associated_with	gene	1.00
AKT	associated_with	gene	1.00
Als	therapeutic_target	disease	1.00
Aging	therapeutic_target	disease	1.00
Cancer	regulates	disease	1.00
Tumor	regulates	disease	1.00
GENES	associated_with	gene	1.00
Alzheimer	activates	disease	1.00
P62	activates	gene	1.00
Cancer	associated_with	disease	1.00
GENES	therapeutic_target	gene	1.00
Inflammation	therapeutic_target	disease	1.00
Neurodegeneration	associated_with	disease	1.00
GENES	regulates	gene	1.00
AMPK	regulates	gene	1.00
Als	regulates	disease	1.00
Inflammation	regulates	disease	1.00
Alzheimer	associated_with	disease	1.00

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
REDD1-mTOR Axis as the Master Regulator — Preservation Over	0.586	neurodegeneration	Why does iron chelation therapy worsen o
TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR	0.451	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which specific metabolic pathways in APOE4 microglia are causally linked to dysf

neurodegeneration | 2026-04-11 | 0 hypotheses

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Trem2-dependent Insl3 regulation via Dap12-Syk-PI3K pathway: A new pathogenic me [PMID:41038403]	Ye S, Wu C, Huang S, Fan H, Zhang Z et a	Genomics	2025	0

Mtor

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Parkinson's Disease

Device Therapies Comparison for CBS/PSP

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

PD Combination Therapy Matrix

Therapeutics

neuroinflammation

CBS/PSP Treatment Rankings

NRF2 Oxidative Stress Pathway

nct07165106

Mitochondrial Quality Control

Astrocyte Reactivity Mechanism

Growth Factor Therapies

ALS Failed Approaches Analysis

Mitochondrial Dysfunction in Parkinson's Disease

Circadian Rhythm in Neurodegeneration

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms