gene 2,754 words KG: TREML1
Contents

TREML1 (TREM Like Transcript 1)

🧬 Gene Info
Gene SymbolTREML1
Chromosome6p21.1
Protein TypeReceptor
Functionis a gene encoding a cell surface receptor belonging to the TREM family.
Primary ExpressionPlatelets, neutrophils, monocytes
Amino Acids260 aa
Exons5
PathwaysPI3K, MAPK, NF-κB pathway
GeneCardsTREML1
Human Protein AtlasTREML1
DAP12 (TYROBP)Direct binding
SYKKinase substrate
TREM2Homology/cluster
HLA-DRPotential interaction
IntegrinsCell adhesion
Associated DiseasesAlzheimer's disease risk, Alzheimer's Disease
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (17)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
TREM2-Dependent Microglial Senescence Transition
Score: 0.69

Related Analyses (5)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
APOE3 (Apolipoprotein E3)
disease · Pages share 4 hypotheses
APOE2 (Apolipoprotein E2)
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses

Knowledge Graph (2 edges)

TREML1 data_in benchmark_ot_ad_answer_key:TREML1
benchmark_ot_ad_answer_key:TREML1 data_in TREML1