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gene 2,754 words KG: TREML1
Contents

TREML1 (TREM Like Transcript 1)

🧬 Gene Info
Gene SymbolTREML1
Chromosome6p21.1
Protein TypeReceptor
Functionis a gene encoding a cell surface receptor belonging to the TREM family.
Primary ExpressionPlatelets, neutrophils, monocytes
Amino Acids260 aa
Exons5
PathwaysPI3K, MAPK, NF-κB pathway
GeneCardsTREML1
Human Protein AtlasTREML1
Associated DiseasesAlzheimer's disease risk, Alzheimer's Disease
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (17)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76APOE Isoform Conversion Therapy
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72APOE-Dependent Autophagy Restoration
Score: 0.89Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74APOE-TREM2 Interaction Modulation
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62TREM2-Dependent Microglial Senescence Transition
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.62TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58

Related Analyses (5)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_innct05508789
clinical_trial · Pages share 4 hypothesesMK-1167 Phase 2 AD Trial (MK-1167-008)
clinical · Pages share 4 hypothesesA Placebo-Controlled, Double-Blind, Parallel-Group, 18-
clinical · Pages share 4 hypothesesLX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 4 hypotheses

Knowledge Graph (2 edges)

TREML1 data_in benchmark_ot_ad_answer_key:TREML1
benchmark_ot_ad_answer_key:TREML1 data_in TREML1

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