gene 2,281 words KG: UGDH 2026-03-27
kind:genesection:genesstate:publishedtopic:ugdhtopic:glycosaminoglycantopic:heparan-sulfatetopic:proteoglycanstopic:dopamine-metabolismtopic:alzheimerstopic:parkinsons
Contents

UGDH — UDP-Glucose 6-Dehydrogenase

🧬 Gene Info
Gene SymbolUGDH
Full NameUDP-Glucose 6-Dehydrogenase
AliasesUGDH: UDP-Glucose 6-Dehydrogenase
Chromosome4p15.1
Protein TypeEnzyme
Functionis a crucial NAD-dependent enzyme that catalyzes the oxidation of UDP-glucose to UDP-glucuronic acid, a key precursor for glycosaminoglycan (GAG) biosynthesis[@barash1999][@wang2000].
Primary Expressionboth neurons and glia, where it contributes to the maintenance of extracellular matrix integrity, neuroinflammation regulation, and cellular stress re
Molecular Weight52 kDa
Amino Acids463 aa
Exons11
UniProt ID[Q9Y2K2](https://www.uniprot.org/uniprot/Q9Y2K2)
Ensembl IDENSG00000108639
GeneCardsUGDH
Human Protein AtlasUGDH
Associated DiseasesAlzheimer's disease, Parkinson's disease
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph