| Gene Symbol | WNT8A |
| Aliases | Wnt Family Member 8A |
| Function | Like all Wnt proteins, WNT8A contains a conserved Wnt1 domain (SMART00097) that is essential for receptor binding and signaling activity. |
| Primary Expression | kidney, heart, intestine during development |
| Amino Acids | 349 aa |
| Pathways | WNT, Wnt, Wnt signaling, Wnt pathway |
| Ensembl ID | ENSG00000068972 |
| GeneCards | WNT8A |
| Human Protein Atlas | WNT8A |
| N-terminal signal peptide | Directs secretion via the secretory pathway |
| Wnt domain | Highly conserved signaling region with multiple cysteine residues forming disulfide bonds |
| Lipid modification | Palmitoylation at a conserved cysteine is required for secretion and activity |
| Glycosylation | N-linked carbohydrates enhance stability and solubility |
| Planar cell polarity (PCP) pathway | Through FZD receptors, activates DVL and small GTPases |
| Wnt/Ca²⁺ pathway | Through FZD and Ror receptors, increases intracellular calcium |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |