gene 628 words KG: GSR 2026-03-24
kind:genesection:genesstate:published
Contents

GSR — Glutathione Reductase

🧬 Gene Info
Gene SymbolGSR
Full NameGlutathione Reductase
Chromosome8p12
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionall tissues
PathwaysEpigenetic
UniProt IDP16455
NCBI Gene ID2935
Ensembl IDENSG00000100647
GeneCardsGSR
Human Protein AtlasGSR
Glutathione (GSH/GSSG)Tripeptide antioxidant substrate and product
Glutathione Peroxidase (GPX)Enzyme utilizing GSH for hydrogen peroxide reduction
Superoxide Dismutase (SOD)Complementary antioxidant enzyme
Associated DiseasesALS
InteractionsCNO, GPX4, VDAC2, DMT1, CYBB, ATF4
KG Connections100 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Knowledge Graph (12 edges)

GSR inhibits CNO
GSR inhibits Lipid Peroxidation
GSR therapeutic_target CNO
GSR inhibits GPX4
GSR activates VDAC2
GSR activates DMT1
GSR activates CYBB
GSR inhibits ATF4
GSR therapeutic_target Rb
GSR co_expressed_with HIF1A