protein 1,015 words KG: ATF4 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

ATF4 Protein

🔬 Protein Info
Gene SymbolATF4
Full NameActivating Transcription Factor 4
Chromosome22q13.1
Protein TypeTranscription Factor
FunctionAmino acid metabolism: Upregulates genes involved in amino acid transport and synthesis
Molecular Weight38.6 kDa
PathwaysApoptosis, Autophagy, Epigenetic, Er Stress, Ferroptosis
UniProt ID[P18848](https://www.uniprot.org/uniprot/P18848)
GeneCardsATF4
Human Protein AtlasATF4
Associated DiseasesAging, Atherosclerosis, CANCER, Glioblastoma, Tumor
Known Drugs/Compoundsrapamycin
InteractionsPPP1R15A, XBP1, DDIT3, HSPA5, RRAGA, JUN
KG Connections566 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (16)

Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Vagal Afferent Microbial Signal Modulation
Score: 0.52
Phase-Separated Organelle Targeting
Score: 0.52
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (14)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: expressed_in
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
ATF3 Gene
gene · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates

Knowledge Graph (12 edges)

ATF4 phosphorylates EIF2A
ATF4 activates FMR1
ATF4 activates G3BP1
ATF4 activates GABARAP
ATF4 activates TIA1
ATF4 mediates INTEGRATED STRESS RESPONSE
ATF4 activates PPP1R15A
ATF4 therapeutic_target IL12B
ATF4 activates XBP1
ATF4 therapeutic_target CXCL1