protein

ATF4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATF4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

566Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ATF4 is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 313 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ATF4
Full Name	Activating Transcription Factor 4
Chromosome	22q13.1
Protein Type	Transcription Factor
Function	Amino acid metabolism: Upregulates genes involved in amino acid transport and synthesis
Molecular Weight	38.6 kDa
Pathways	Apoptosis, Autophagy, Epigenetic, Er Stress, Ferroptosis
UniProt ID	[P18848](https://www.uniprot.org/uniprot/P18848)
GeneCards	ATF4
Human Protein Atlas	ATF4
Associated Diseases	Aging, Atherosclerosis, CANCER, Glioblastoma, Tumor
Known Drugs/Compounds	rapamycin
Interactions	PPP1R15A, XBP1, DDIT3, HSPA5, RRAGA, JUN
KG Connections	566 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATF4["ATF4"] -->|"regulates"| mitophagy["mitophagy"]
    ATF4["ATF4"] -->|"therapeutic target"| Ms["Ms"]
    ATF4["ATF4"] -->|"therapeutic target"| Als["Als"]
    ATF4["ATF4"] -->|"interacts"| Cancer["Cancer"]
    ATF4["ATF4"] -->|"interacts"| Aging["Aging"]
    ATF4["ATF4"] -->|"interacts"| Ms_1["Ms"]
    CXCL2["CXCL2"] -->|"therapeutic target"| ATF4["ATF4"]
    IL6["IL6"] -->|"therapeutic target"| ATF4["ATF4"]
    GABARAP["GABARAP"] -->|"associated"| ATF4["ATF4"]
    RANK["RANK"] -->|"regulates"| ATF4["ATF4"]
    style ATF4 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (357)

Target	Relation	Type	Str
Integrated Stress Response	regulates	pathway	0.88
Apoptosis	upregulates	process	0.88
Integrated Stress Response	mediates	pathway	0.85
Cell Death	promotes	phenotype	0.85
integrated stress response	promotes	pathway	0.85
Als	activates	disease	0.85
INTEGRATED STRESS RESPONSE	mediates	entity	0.85
Apoptosis	promotes	process	0.85
Er Stress	activates	pathway	0.80
Endoplasmic Reticulum Stress	biomarker_for	process	0.75
Als	regulates	disease	0.75
Tumor	activates	disease	0.75
DDIT3	activates	gene	0.70
mitophagy	regulates	process	0.70
Mtor	activates	pathway	0.70
Mitophagy	activates	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Leukemia	regulates	disease	0.65
Ms	activates	disease	0.65
Aging	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Ms	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Tumor	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Glioblastoma	activates	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Diabetes	inhibits	disease	0.65
Cardiac	inhibits	disease	0.65
Senescence	activates	disease	0.65
ALS	activates	disease	0.65
ALS	interacts_with	disease	0.65
ALS	regulates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Glioma	activates	disease	0.65
Fibrosis	activates	disease	0.65

Incoming (209)

Source	Relation	Type	Str
Identified Compounds	upregulates	compound	0.90
PERK	upregulates	protein	0.85
ATG2A-G433A	upregulates	variant	0.85
DTG	upregulates	drug	0.85
EFTUD2	regulates	gene	0.85
DDIT3	upregulates	gene	0.80
PERK	activates	gene	0.70
APOE4	inhibits	protein	0.70
APOPTOSIS	activates	gene	0.70
MITOPHAGY	activates	gene	0.70
CXCL2	therapeutic_target	gene	0.60
IL6	therapeutic_target	gene	0.60
GABARAP	associated_with	gene	0.60
RANK	regulates	gene	0.60
RANKL	regulates	gene	0.60
TSC2	regulates	gene	0.60
ERK2	activates	gene	0.60
TSC1	regulates	gene	0.60
MTOR	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
MTOR	inhibits	gene	0.60
ATG12	regulates	gene	0.60
EIF2A	activates	gene	0.60
CAT	regulates	gene	0.60
ATG3	regulates	gene	0.60
ATG10	regulates	gene	0.60
SESN2	activates	gene	0.60
P62	activates	gene	0.60
KEAP1	activates	gene	0.60
GPX4	inhibits	gene	0.60
CAT	biomarker_for	gene	0.60
GPX4	biomarker_for	gene	0.60
RELA	expressed_in	gene	0.60
MYC	expressed_in	gene	0.60
SP1	expressed_in	gene	0.60
IRF7	expressed_in	gene	0.60
PPARGC1A	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
BAP1	regulates	gene	0.60
SLC7A11	regulates	gene	0.60
TAZ	associated_with	gene	0.60
SATB2	associated_with	gene	0.60
PIEZO1	regulates	gene	0.60
PUMA	therapeutic_target	gene	0.60
MTOR	activates	gene	0.60
AKT	activates	gene	0.60
NOXA	activates	gene	0.60
MDM2	activates	gene	0.60
CDK4	activates	gene	0.60
SEL1L	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ATF4

Understanding Entity Pages

Summary

Wiki Pages (21)

ATF4 Gene

RPL30 — Ribosomal Protein L30 in Neurodegeneration

tudca-udca-neurodegeneration

Transcriptional Regulation in Neurodegeneration

er-stress-neurodegeneration

Unfolded Protein Response (UPR)

Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

SETD1B

PKR Pathway in Neurodegeneration

endoplasmic-reticulum-stress

Stress Granule Dysfunction Hypothesis in Parkinson's Disease

ERP57 (PDIA3) — Protein Disulfide Isomerase Family A Member 3

Mitochondrial Unfolded Protein Response in Neurodegeneration

NAD+ Metabolism in Neurodegeneration

ATF3 Protein

ER Stress in Corticobasal Syndrome

PPP1R15B

proteostasis-triad-pulses

Integrated Stress Response in Alzheimer's Disease