gene

CYBB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYBB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

127Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for CYBB — Cytochrome b-245, Beta Polypeptide

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🧬 Gene Info

Gene Symbol	CYBB
Full Name	Cytochrome b-245, Beta Polypeptide (NADPH Oxidase Subunit)
Aliases	Cytochrome b-245, Beta Polypeptide
Chromosome	Xp21.1
Function	The CYBB gene encodes the gp91^phox^ subunit (also called NOX2), which is the catalytic core of the NADPH oxidase (NOX2) enzyme complex.
Amino Acids	570 aa
Pathways	COMPLEMENT, complement cascade
UniProt ID	P04839
NCBI Gene ID	1539
Ensembl ID	ENSG00165195
OMIM	306500
GeneCards	CYBB
Human Protein Atlas	CYBB
Associated Diseases	ALS, Aging, Atrial Fibrillation, Chronic Granulomatous Disease, Depression
Interactions	ATF4, ITGAM, C1QC, CD68, NRF2, HMOX1
KG Connections	127 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CYBB — AlphaFold P04839 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CYBB["<b>CYBB</b>"]
    Als{"Als"}
    CYBB -->|"expressed in"| Als
    neurodegeneration["neurodegeneration"]
    CYBB -->|"implicated in"| neurodegeneration
    CTSB["CTSB"]
    CTSB -->|"associated with"| CYBB
    ABCA1["ABCA1"]
    ABCA1 -->|"associated with"| CYBB
    MIRNAS["MIRNAS"]
    MIRNAS -->|"expressed in"| CYBB
    CTSD["CTSD"]
    CTSD -->|"associated with"| CYBB
    style CYBB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (74)

Target	Relation	Type	Str
PITX2	upregulates	gene	0.80
Chronic Granulomatous Disease	causes	disease	0.80
Recurrent Spontaneous Abortion	biomarker_for	disease	0.80
Obesity	contributes_to	disease	0.80
Atrial Fibrillation	causes	disease	0.70
Ischemic Stroke	associated_with	disease	0.70
Depression	associated_with	disease	0.70
Als	expressed_in	disease	0.65
Lupus	associated_with	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Ferroptosis	activates	disease	0.65
Als	activates	disease	0.65
Diabetes	activates	disease	0.65
ALS	associated_with	disease	0.65
LRRK2	associated_with	gene	0.60
LC3	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
DRAM1	associated_with	gene	0.60
C1QC	biomarker_for	gene	0.60
C4B	biomarker_for	gene	0.60
ITGAM	biomarker_for	gene	0.60
C1QA	biomarker_for	gene	0.60
CSF1R	associated_with	gene	0.60
C1QA	associated_with	gene	0.60
C3AR1	associated_with	gene	0.60
ATF4	activates	gene	0.60
AIF1	biomarker_for	gene	0.60
CD163	associated_with	gene	0.60
CD4	associated_with	gene	0.60
AIF1	associated_with	gene	0.60
C1QB	associated_with	gene	0.60
CCR1	associated_with	gene	0.60
CD68	biomarker_for	gene	0.60
TYROBP	associated_with	gene	0.60
TMEM119	biomarker_for	gene	0.60
TREM2	biomarker_for	gene	0.60
C1QB	biomarker_for	gene	0.60
complement cascade	participates_in	pathway	0.60
MTORC1	associated_with	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
DNA	associated_with	gene	0.60
IFN	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
Immune Response	associated_with	pathway	0.60
Phagocytosis	associated_with	pathway	0.60
Adaptive Immunity	associated_with	pathway	0.60
MICROGLIA	biomarker_for	gene	0.60

Incoming (53)

Source	Relation	Type	Str
CTSB	associated_with	gene	0.60
ABCA1	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
ATG16L2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
CDKN1B	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
RUBCN	associated_with	gene	0.60
C1QB	biomarker_for	gene	0.60
TMEM119	biomarker_for	gene	0.60
AIF1	biomarker_for	gene	0.60
TYROBP	associated_with	gene	0.60
TREM2	biomarker_for	gene	0.60
CD68	biomarker_for	gene	0.60
CCR1	associated_with	gene	0.60
C1QB	associated_with	gene	0.60
CD4	associated_with	gene	0.60
AIF1	associated_with	gene	0.60
CD163	associated_with	gene	0.60
NRF2	activates	gene	0.60
HMOX1	activates	gene	0.60
APP	activates	gene	0.60
GSR	activates	gene	0.60
GPX4	activates	gene	0.60
VDAC2	activates	gene	0.60
DMT1	activates	gene	0.60
ITGAM	biomarker_for	gene	0.60
C1QC	biomarker_for	gene	0.60
C1QA	biomarker_for	gene	0.60
C4B	biomarker_for	gene	0.60
C3AR1	associated_with	gene	0.60
CD86	associated_with	gene	0.60
MIRNAS	expressed_in	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
LPCAT3	activates	gene	0.60
ROS	activates	gene	0.60
AMYLOID	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
AGING	associated_with	gene	0.60
INOS	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
TREM2	activates	gene	0.50
AIF1	activates	gene	0.50
TMEM119	activates	gene	0.50
C1QB	activates	gene	0.50
C1QA	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CYBB

Understanding Entity Pages

Summary

Wiki Pages (18)

CYBB — Cytochrome b-245, Beta Polypeptide

NCF4 (Neutrophil Cytosolic Factor 4)

NOX2 Gene

Dopaminergic Neurodegeneration

CCR1

CDKN1B — Cyclin-Dependent Kinase Inhibitor 1B

XK Gene

nadph-oxidase-inhibitors

ATG16L2 Gene

NOXA1 Protein

NOX2/CYBB (NADPH Oxidase 2)

NOXO1 Protein

p67phox Protein

NCF1 — Neutrophil Cytosolic Factor 1

NADPH Oxidase 2

NCF2 Gene